Reverse Chemical Proteomics: Harnessing Yeast Display for Drug Discovery

This Project aims to overcome a critical bottleneck in the drug discovery process by developing a technique that can rapidly identify the cellular protein targets of biologically active natural products. This Project expects to provide fundamental biological and chemical insights into Australia's unique biodiversity that will facilitate the development of new therapeutic agents and agrochemicals based on leads provided by Nature. Expected outcomes of this Project include an optimised and validated platform technology for accelerating drug discovery and development. This should substantially reduce the costs associated with fighting human and animal diseases, leading to improved health, productivity and quality of life.