Project Details
Description
Alzheimer’s disease is the most common form of demen8a. Abnormal clumps of two proteins, known as amyloid-beta plaques and tau tangles, cause the death of cells in the brains of pa8ents. Currently, there is no cure for Alzheimer’s disease, although there are symptoma8c treatments and suppor8ve measures. In this project, we aim to target and prevent the toxic effects of the tau protein, which we believe will lead to improved clinical outcomes in people with Alzheimer’s disease.
Recent advances in ar8ficial intelligence technology has made it possible to study protein
interac8ons with more precision and detail. In this project, we mapped the surface of a tau-based protein complex involved in toxic cell signalling. Using this informa8on, we have designed novel chemical molecules to disrupt the toxic protein complex. We hypothesise that blocking the forma8on of this toxic complex will prevent the death of brain cells in Alzheimer’s disease, and thereby reduce clinical symptoms.
Recent advances in ar8ficial intelligence technology has made it possible to study protein
interac8ons with more precision and detail. In this project, we mapped the surface of a tau-based protein complex involved in toxic cell signalling. Using this informa8on, we have designed novel chemical molecules to disrupt the toxic protein complex. We hypothesise that blocking the forma8on of this toxic complex will prevent the death of brain cells in Alzheimer’s disease, and thereby reduce clinical symptoms.
| Status | Active |
|---|---|
| Effective start/end date | 15/05/25 → 14/05/26 |