Stronger Together: Understanding Antibiotic Synergy on a Molecular Level

Research output

Research output per year 2019 2020 2021 2022 2023 2024

• 20 Article
• 3 Review article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  A method to correct for local alterations in DNA copy number that bias functional genomics assays applied to antibiotic-treated bacteria

  Sullivan, G. J., Barquist, L. & Cain, A. K., Apr 2024, In: mSystems. 9, 4, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Functional Genomics 100%
  • Antibiotics 83%
  • Bacteria 70%
  • Sequencing 68%
  • Assays 66%
  1 Citation (Scopus)

  58 Downloads (Pure)
• 2023

  Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence

  Semenec, L., Cain, A. K., Dawson, C. J., Liu, Q., Dinh, H., Lott, H., Penesyan, A., Maharjan, R., Short, F. L., Hassan, K. A. & Paulsen, I. T., 9 Feb 2023, In: Nature Communications. 14, 1, p. 1-18 18 p., 702.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Klebsiella 100%
  • pneumonia 96%
  • Cefotaxime 86%
  • Cross Protection 82%
  • infectious diseases 73%
  44 Citations (Scopus)

  157 Downloads (Pure)

• DksA is a conserved master regulator of stress response in Acinetobacter baumannii

  Maharjan, R. P., Sullivan, G. J., Adams, F. G., Shah, B. S., Hawkey, J., Delgado, N., Semenec, L., Dinh, H., Li, L., Short, F. L., Parkhill, J., Paulsen, I. T., Barquist, L., Eijkelkamp, B. A. & Cain, A. K., 7 Jul 2023, In: Nucleic Acids Research. 51, 12, p. 6101-6119 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Acinetobacter baumannii 100%
  • Virulence 71%
  • Phenomics 70%
  • Gammaproteobacteria 60%
  • Desiccation 60%
  3 Citations (Scopus)

  83 Downloads (Pure)

• Identification of a novel LysR family transcriptional regulator controlling acquisition of sulfur sources in Acinetobacter baumannii

  Pokhrel, A., Dinh, H., Li, L., Hassan, K. A., Cain, A. K. & Paulsen, I. T., 2023, In: Microbial Physiology. 33, 1, p. 27-35 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Acinetobacter baumannii 100%
  • Sulfur 96%
  • Biosynthesis 68%
  • Cysteine 47%
  • L-Cysteine 32%
  3 Citations (Scopus)

  67 Downloads (Pure)

• Microfluidic separation and enrichment of Escherichia coli by size using viscoelastic flows

  Zhang, T., Cain, A. K., Semenec, L., Liu, L., Hosokawa, Y., Inglis, D. W., Yalikun, Y. & Li, M., 31 Jan 2023, In: Analytical Chemistry. 95, 4, p. 2561-2569 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Cluster 100%
  • Flow 99%
  • Poly(ethylene) 29%
  • Flow Kinetics 23%
  • Force 20%
  21 Citations (Scopus)

• Systematic analyses identify modes of action of ten clinically relevant biocides and antibiotic antagonism in Acinetobacter baumannii

  Li, L., Short, F. L., Hassan, K. A., Naidu, V., Pokhrel, A., Nagy, S. S., Prity, F. T., Shah, B. S., Afrin, N., Baker, S., Parkhill, J., Cain, A. K. & Paulsen, I. T., Nov 2023, In: Nature Microbiology. 8, 11, p. 1995-2005 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Disinfectants 100%
  • Acinetobacter baumannii 99%
  • Anti-Bacterial Agents 53%
  • Cell Respiration 32%
  • Bacteria 15%
  12 Citations (Scopus)
• 2022

  Genomic and phenotypic analyses of diverse non-clinical Acinetobacter baumannii strains reveals strain-specific virulence and resistance capacity

  Hamidian, M., Maharjan, R. P., Farrugia, D. N., Delgado, N. N., Dinh, H., Short, F. L., Kostoulias, X., Peleg, A. Y., Paulsen, I. T. & Cain, A. K., 2022, In: Microbial Genomics. 8, 2, p. 1-19 19 p., 000765.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Acinetobacter baumannii 100%
  • Virulence 71%
  • Microbial Drug Resistance 27%
  • Phenomics 23%
  • Acinetobacter Infections 20%
  12 Citations (Scopus)

  231 Downloads (Pure)

• Length-based separation of Bacillus subtilis bacterial populations by viscoelastic microfluidics

  Liu, P., Liu, H., Semenec, L., Yuan, D., Yan, S., Cain, A. K. & Li, M., 19 Jan 2022, In: Microsystems and Nanoengineering. 8, 1, p. 1-11 11 p., 7.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polyethylene oxides 100%
  • Bacilli 94%
  • Bacillus 88%
  • Bacteria 73%
  • Microfluidics 69%
  23 Citations (Scopus)

  92 Downloads (Pure)

• Metal complexes as antifungals? From a crowd-sourced compound library to the first in vivo experiments

  Frei, A., Elliott, A. G., Kan, A., Dinh, H., Bräse, S., Bruce, A. E., Bruce, M. R., Chen, F., Humaidy, D., Jung, N., King, A. P., Lye, P. G., Maliszewska, H. K., Mansour, A. M., Matiadis, D., Muñoz, M. P., Pai, T-Y., Pokhrel, S., Sadler, P. J., Sagnou, M., & 8 othersTaylor, M., Wilson, J. J., Woods, D., Zuegg, J., Meyer, W., Cain, A. K., Cooper, M. A. & Blaskovich, M. A. T., 24 Oct 2022, In: Journal of the American Chemical Society. 2, 10, p. 2277-2294 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Metal complexes 100%
  • Coordination Complexes 91%
  • Libraries 54%
  • Metals 53%
  • Drug Discovery 41%
  45 Citations (Scopus)

  65 Downloads (Pure)

• Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics

  Zhang, T., Liu, H., Okano, K., Tang, T., Inoue, K., Yamazaki, Y., Kamikubo, H., Cain, A. K., Tanaka, Y., Inglis, D. W., Hosokawa, Y., Yaxiaer, Y. & Li, M., 7 Aug 2022, In: Lab on a Chip. 22, 15, p. 2801-2809 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Escherichia coli 100%
  • Microfluidics 94%
  • Shape 51%
  • Aspect ratio 45%
  • Mecillinam 37%
  22 Citations (Scopus)
• 2021

  Editorial: secondary effects of antibiotic exposure

  Cain, A. K., Nolan, L. M., Cornick, J. & Hassan, K. A., Aug 2021, In: Frontiers in Microbiology. 12, p. 1-3 3 p., 737958.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  1 Citation (Scopus)

  34 Downloads (Pure)

• Genomic investigation of a suspected Klebsiella pneumoniae outbreak in a neonatal care unit in sub-Saharan Africa

  Cornick, J., Musicha, P., Peno, C., Seager, E., Tam, P-Y. I., Bilima, S., Bennett, A., Kennedy, N., Feasey, N., Heinz, E. & Cain, A. K., 2021, In: Microbial Genomics. 7, 11, p. 1-6 6 p., 000703.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Africa South of the Sahara 100%
  • Klebsiella pneumoniae 96%
  • Disease Outbreaks 80%
  • Plasmids 48%
  • Malawi 39%
  7 Citations (Scopus)

  25 Downloads (Pure)

• Microbiology's next top model: Galleria in the molecular age

  Dinh, H., Semenec, L., Kumar, S. S., Short, F. L. & Cain, A. K., Mar 2021, In: Pathogens and Disease. 79, 2, p. 1-11 11 p., ftab006.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Microbiology 100%
  • Virulence 82%
  • Invertebrates 53%
  • Life Cycle Stages 50%
  • Body Temperature 48%
  31 Citations (Scopus)

• Nontoxic cobalt(III) Schiff base complexes with broad‐spectrum antifungal activity

  Frei, A., King, A. P., Lowe, G. J., Cain, A. K., Short, F. L., Dinh, H., Elliott, A. G., Zuegg, J., Wilson, J. J. & Blaskovich, M. A. T., 26 Jan 2021, In: Chemistry - A European Journal. 27, 6, p. 2021-2029 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Candida 100%
  • Metal complexes 99%
  • Cytotoxicity 90%
  • Yeast 73%
  • Toxicity 72%
  43 Citations (Scopus)

  58 Downloads (Pure)

• Platinum cyclooctadiene complexes with activity against gram-positive bacteria

  Frei, A., Ramu, S., Lowe, G. J., Dinh, H., Semenec, L., Elliott, A. G., Zuegg, J., Deckers, A., Jung, N., Bräse, S., Cain, A. K. & Blaskovich, M. A. T., 15 Oct 2021, In: ChemMedChem. 16, 20, p. 3165-3171 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gram-Positive Bacteria 100%
  • Platinum 95%
  • Inorganic Chemistry 88%
  • Organic Chemistry 79%
  • Methicillin 68%
  28 Citations (Scopus)

  56 Downloads (Pure)

• The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

  Alquethamy, S. F., Adams, F. G., Maharjan, R., Delgado, N. N., Zang, M., Ganio, K., Paton, J. C., Hassan, K. A., Paulsen, I. T., McDevitt, C. A., Cain, A. K. & Eijkelkamp, B. A., Oct 2021, In: Applied and Environmental Microbiology. 87, 22, p. 1-11 11 p., e01718-21.

  Research output: Contribution to journal › Article › peer-review

  • Acinetobacter baumannii 100%
  • Cadmium 83%
  • cadmium 65%
  • toxicity 54%
  • metal ions 31%
  13 Citations (Scopus)

• Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance

  Stenhouse, G. E., Jere, K. C., Peno, C., Bengtsson, R. J., Chinyama, E., Mandolo, J., Cain, A., Iturriza-Gómara, M., Bar-Zeev, N., Cunliffe, N. A., Cornick, J. & Baker, K. S., 2021, In: Microbial Genomics. 7, 5, p. 1-6 6 p., 000532.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Malawi 100%
  • Shigella 96%
  • Fluoroquinolones 86%
  • Sequence Analysis 71%
  • Genome 52%
  3 Citations (Scopus)

  64 Downloads (Pure)
• 2020

  A decade of advances in transposon-insertion sequencing

  Cain, A. K., Barquist, L., Goodman, A. L., Paulsen, I. T., Parkhill, J. & van Opijnen, T., Sept 2020, In: Nature Reviews Genetics. 21, 9, p. 526-540 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Genome 100%
  • Bacterial Genomes 98%
  • Mutagenesis 72%
  • High-Throughput Nucleotide Sequencing 70%
  • Genotype 52%
  241 Citations (Scopus)

  73 Downloads (Pure)

• A global data-driven census of Salmonella small proteins and their potential functions in bacterial virulence

  Venturini, E., Svensson, S. L., Maaß, S., Gelhausen, R., Eggenhofer, F., Li, L., Cain, A. K., Parkhill, J., Becher, D., Backofen, R., Barquist, L., Sharma, C. M., Westermann, A. J. & Vogel, J., 2020, In: microLife. 1, 1, p. 1-20 20 p., uqaa002.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Censuses 100%
  • Salmonella 96%
  • Virulence 80%
  • Proteins 33%
  • Proteome 32%
  36 Citations (Scopus)

  29 Downloads (Pure)

• How antibiotics work together: molecular mechanisms behind combination therapy

  Sullivan, G. J., Delgado, N. N., Maharjan, R. & Cain, A. K., Oct 2020, In: Current Opinion in Microbiology. 57, p. 31-40 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Anti-Bacterial Agents 100%
  • Bacterial Infections 28%
  • Communicable Diseases 26%
  • Tuberculosis 25%
  • Therapeutics 24%
  60 Citations (Scopus)

  222 Downloads (Pure)

• Identification of genes required for the fitness of Streptococcus equi subsp. equi in whole equine blood and hydrogen peroxide

  Charbonneau, A. R. L., Taylor, E., Mitchell, C. J., Robinson, C., Cain, A. K., Leigh, J. A., Maskell, D. J. & Waller, A. S., Apr 2020, In: Microbial Genomics. 6, 4, p. 1-15 15 p., 000362.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Streptococcus equi 100%
  • Hydrogen Peroxide 62%
  • Horses 59%
  • Genes 25%
  • Attenuated Vaccines 22%
  6 Citations (Scopus)

  65 Downloads (Pure)

• The transcriptomic signature of tigecycline in Acinetobacter baumannii

  Li, L., Hassan, K. A., Tetu, S. G., Naidu, V., Pokhrel, A., Cain, A. K. & Paulsen, I. T., 27 Oct 2020, In: Frontiers in Microbiology. 11, p. 1-11 11 p., 565438.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tigecycline 100%
  • Acinetobacter baumannii 89%
  • Ribosomes 28%
  • Genes 14%
  • Toxin-Antitoxin Systems 14%
  12 Citations (Scopus)

  92 Downloads (Pure)
• 2019

  Complete genome sequence of Pseudomonas aeruginosa reference strain PAK

  Cain, A. K., Nolan, L. M., Sullivan, G. J., Whitchurch, C. B., Filloux, A. & Parkhill, J., Oct 2019, In: Microbiology Resource Announcements. 8, 41, p. 1-3 3 p., e00865-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pseudomonas aeruginosa 100%
  • Genome 73%
  • Virulence Factors 56%
  23 Citations (Scopus)

  60 Downloads (Pure)

• Contrasting patterns of longitudinal population dynamics and antimicrobial resistance mechanisms in two priority bacterial pathogens over 7 years in a single center

  Ellington, M. J., Heinz, E., Wailan, A. M., Dorman, M. J., De Goffau, M., Cain, A. K., Henson, S. P., Gleadall, N., Boinett, C. J., Dougan, G., Brown, N. M., Woodford, N., Parkhill, J., Török, M. E., Peacock, S. J. & Thomson, N. R., 2 Sept 2019, In: Genome Biology. 20, p. 1-16 16 p., 184.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Enterobacter cloacae 100%
  • Population Dynamics 89%
  • resistance mechanisms 76%
  • antibiotic resistance 72%
  • population dynamics 70%
  18 Citations (Scopus)

  54 Downloads (Pure)