Uncovering Central Gain Mechanisms In The Subcortex

Central gain is a delicate balance of inhibitory and excitatory neurons in the brain. When disturbed, it can lead to run-away gain, like the screech of loudspeakers in a public address system when a microphone is brought closer. Except, in the auditory brain it can lead to tinnitus – phantom ringing – and hyperacusis – reduced tolerance to loud sounds.

We are studying mechanisms in the human auditory brainstem using non-invasive techniques that has the potential to detect subtle changes in central gain early, ie before individuals develop hearing loss, tinnitus, and hyperacusis. Such early detection can help in earlier administration of therapeutics or changing lifestyle.