Understanding the immune contexture and signalling crosstalk between tumour and immune cells in glioblastoma

This project aims to design new patient-tailored therapies for glioblastoma, the most common and aggressive brain cancer, and to develop a platform for comprehensive analysis of tumour specimens that is scalable and applicable to various cancers. Cell models will be generated from fresh specimens for future use. In-depth analysis of immune cell function, combined with genetic engineering and use of novel 3D co-culture cell models, will be employed to study tumour-immune interactions, model immune resistance mechanisms and discover novel therapeutic targets. Our results may lead to improved outcomes for glioblastoma patients and to the establishment of a cancer biobank-compliant platform for patient sample analysis.