Project Details
Description
Heart disease is a leading cause of death in individuals with chronic kidney disease (CKD). Emerging evidence suggests the risk of heart disease is not equal in men and women and contrary to popular belief, women are in fact at greater risk. Fundamental differences must therefore exist in the development of heart disease between the sexes. Increased activity
of the sympathetic nervous system, specifically targeted towards the heart could be a key factor. We have pilot data showing heart disease in a rodent model of CKD and critically, that there is increased sympathetic nerve activity to the heart of females vs. males. To address this, we will test the following hypotheses: In female rats with CKD (1) cardiac noradrenaline homeostasis in the heart is inappropriately regulated (2) the heart responds excessively to noradrenaline and (3) chronic inhibition of the sympathetic nervous system
protects against the development of heart disease.
of the sympathetic nervous system, specifically targeted towards the heart could be a key factor. We have pilot data showing heart disease in a rodent model of CKD and critically, that there is increased sympathetic nerve activity to the heart of females vs. males. To address this, we will test the following hypotheses: In female rats with CKD (1) cardiac noradrenaline homeostasis in the heart is inappropriately regulated (2) the heart responds excessively to noradrenaline and (3) chronic inhibition of the sympathetic nervous system
protects against the development of heart disease.
| Short title | Women's hearts |
|---|---|
| Acronym | OOA_Perpetual |
| Status | Finished |
| Effective start/end date | 1/07/18 → 1/07/19 |