β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia

P. Bourgeat*, G. Chételat, V. L. Villemagne, J. Fripp, P. Raniga, K. Pike, O. Acosta, C. Szoeke, S. Ourselin, D. Ames, K. A. Ellis, R. N. Martins, C. L. Masters, C. C. Rowe, O. Salvado

*Corresponding author for this work

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Objective: To investigate whether global and regional β-amyloid (Aβ) burden as measured with C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). METHODS: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. RESULTS: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. CONCLUSIONS: The strong correlation between hippocampal atrophy and β-amyloid (Aβ) burden in the Pittsburgh compound B-positive healthy control group suggests that Aβ deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalNeurology
Volume74
Issue number2
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

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