Abstract
Objective: To optimize supercritical fluid technology by response surface methodology for preparing curcumin liposome.
Methods: The effects and interaction of three factors on encapsulation efficiency of curcumin liposome, such as SPC concentration, soy phosphatidyl choline （SPC）/curcumin （Cur）, and pH, were investigated by the method of central composite design. Quadratic regression models were set up ac- cording to the experimental data. Response surfaces were delineated on the basis of best fit mathematic models.
Results: Using supercritical fluid technology to prepare curcumin liposome was feasible. The optimal technology conditions of curcumin liposome were as follows: the SPC concentration was 51.16 g. L-1, the ratio of SPC/Cur was 24. 04：1 and pH was 6. 28.
Conclusions: The results show that the encapsulation efficiency of the curcumin liposome is 80. 43 % under the optimal conditions. And there exists small deviation between the measured value of index and model predicted value of 79.55%. It shows that the response surface analytical method is reliable and can be used in the process of prescription optimization.
Methods: The effects and interaction of three factors on encapsulation efficiency of curcumin liposome, such as SPC concentration, soy phosphatidyl choline （SPC）/curcumin （Cur）, and pH, were investigated by the method of central composite design. Quadratic regression models were set up ac- cording to the experimental data. Response surfaces were delineated on the basis of best fit mathematic models.
Results: Using supercritical fluid technology to prepare curcumin liposome was feasible. The optimal technology conditions of curcumin liposome were as follows: the SPC concentration was 51.16 g. L-1, the ratio of SPC/Cur was 24. 04：1 and pH was 6. 28.
Conclusions: The results show that the encapsulation efficiency of the curcumin liposome is 80. 43 % under the optimal conditions. And there exists small deviation between the measured value of index and model predicted value of 79.55%. It shows that the response surface analytical method is reliable and can be used in the process of prescription optimization.
| Translated title of the contribution | Optimization of technology for supercritical fluid technology in preparation of curcumin liposome |
|---|---|
| Original language | Chinese (Simplified) |
| Pages (from-to) | 81-86 |
| Number of pages | 7 |
| Journal | Journal of Shenyang Pharmaceutical University |
| Volume | 2014 |
| Issue number | 2 |
| Publication status | Published - 2014 |
| Externally published | Yes |
Keywords
- supercritical fluid technology
- curcumin
- liposome
- response surface methodology