Abstract
采用超临界CO2制备姜黄素羟丙基-β-环糊精包合物,以增加姜黄素在水中的溶解度.利用单因素法和Box-Behnken响应面设计法以溶解度为评价指标优化包合物的制备工艺.结果表明,最佳制备工艺为包合温度57℃,包合时间2h,压力24MPa,药物与羟丙基-β-环糊摩尔比0.96∶1.所得包合物中姜黄素溶解度为34.24 μg/ml,约是原药的400倍.差示扫描量热分析结果表明,药物与羟丙基-β-环糊精形成了包合物.
| Translated title of the contribution | Preparation of Curcumin Hydroxypropyl-β-cyclodextrin Inclusion Complexes with Supercritical CO2 |
|---|---|
| Original language | Chinese (Simplified) |
| Pages (from-to) | 1147-1150 |
| Number of pages | 5 |
| Journal | Chinese Journal of Pharmaceuticals |
| Volume | 2014 |
| Issue number | 12 |
| Publication status | Published - 1 May 2014 |
| Externally published | Yes |
Keywords
- supercritical CO2
- curcumin
- hydroxypropyl-β-cyclodextrin
- inclusion complex
- solubility