10q deletions in metastatic cutaneous melanoma

James O. Indsto, Elizabeth A. Holland, Richard F. Kefford, Graham J. Mann*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cytogenetic and allelic deletion studies have indicated that the loss of distal chromosome 10q may be a frequent and early event in melanoma tumorigenesis. We have studied nine polymorphic markers spanning 56 cM of this region in 27 advanced melanomas and find that half exhibited loss of the entire region, but none had more limited deletions. Because all these tumors had a codeletion of 9p, the 10q deletion event is likely to impair a pathway other than the cyclin-dependent kinase-mediated phosphorylation of the retinoblastoma protein.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume100
Issue number1
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

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