5-HT disturbs interaction between gut epithelium and commensal bacteria

Sushil Regmi, Sina Shadfar, Ganesh Neupane, Jintae Lee, Jin-Hyung Lee, Jung-Ae Kim*

*Corresponding author for this work

Research output: Contribution to journalMeeting abstract

Abstract

The gut is considered as one of immune privilege sites, which is developed by complex interplay between gut microbiome and the intestinal epithelial barrier. The mechanisms regulating gut tolerance to the commensal bacteria also play an important role in the protection of intestine against epithelial injury. Human studies in patients with inflammatory bowel disease (IBD) have implicated aberrant communication between host and gut flora such as inappropriate immune responses against their own flora. In addition to the excessive production of proinflammatory cytokines, serotonin (5-hydroxytryptamine, 5-HT), an enteric neurotransmitter and paracrine hormone, is also increased in the gut of IBD patients, suggesting its role in the pathogenesis of IBD. In the present study, we examined the role of 5-HT in aberrant communication between gut epithelial cells and commensal bacteria (E coli).
Original languageEnglish
Article number653.10
Number of pages1
JournalFASEB Journal
Volume28
Issue numberS1
DOIs
Publication statusPublished - Apr 2014
Externally publishedYes

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