5-123I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment

Emma Terrière, Mary F. Dempsey, Lucie L. Herrmann, Kevin M. Tierney, Jane A. Lonie, Ronan E. O'Carroll, Sally Pimlott, David J. Wyper, Karl Herholz, Klaus P. Ebmeier*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of illness and treatment suitability. In this pilot, we examined nine patients with amnestic mild cognitive impairment (MCI) and 10 age and education matched healthy volunteers with high resolution SPECT and the nicotinic receptor ligand 5-123I-A-85380. Uptake data were analysed using voxel-based techniques for group comparisons and regression analyses with cognitive impairment as covariates. MCI patients had discrete reductions in uptake in medial temporal cortex. Correlations with cognitive impairment were found in left temporo-parietal areas (Addenbrooke's Cognitive Examination) and bilateral temporo-limbic areas (Rey Auditory Verbal Learning Test), and right parahippocampal gyrus (Rey Complex Figure Test) within the patient group. In vivo nicotinic receptor binding appears to be sensitive to brain changes in MCI. Larger scale explorations of patients undergoing treatment will be necessary to evaluate its use in predicting or monitoring treatment response.

Original languageEnglish
Pages (from-to)1885-1893
Number of pages9
JournalNeurobiology of Aging
Volume31
Issue number11
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amnestic
  • Dementia
  • Mild cognitive impairment
  • Nicotinic acetylcholine receptors
  • Single photon emission tomography

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    Terrière, E., Dempsey, M. F., Herrmann, L. L., Tierney, K. M., Lonie, J. A., O'Carroll, R. E., ... Ebmeier, K. P. (2010). 5-123I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment. Neurobiology of Aging, 31(11), 1885-1893. https://doi.org/10.1016/j.neurobiolaging.2008.10.008