TY - JOUR
T1 - 9-(5-deoxy-5-thio - D-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer
T2 - The first natural occurrence of a nucleoside disulfide
AU - Peng, Chongsheng
AU - Gunaherath, G. M Kamal B
AU - Piggott, Andrew M.
AU - Khalil, Zeinab
AU - Conte, Melissa
AU - Capon, Robert J.
PY - 2010
Y1 - 2010
N2 - Chemical fractionation of a southern Australian marine sponge, Trachycladus laevispirulifer, yielded 9-(5′-deoxy-5′-thio - d-xylofuranosyl) adenine disulfide as the first recorded natural occurrence of a nucleoside disulfide, and only the second of a xylo-nucleoside. Structure elucidation of the disulfide was achieved by detailed spectroscopic analysis and comparison to synthetic model compounds. The antibacterial, antifungal, and anticancer properties of the disulfide are documented and the literature surrounding natural and synthetic thionucleosides is reviewed.
AB - Chemical fractionation of a southern Australian marine sponge, Trachycladus laevispirulifer, yielded 9-(5′-deoxy-5′-thio - d-xylofuranosyl) adenine disulfide as the first recorded natural occurrence of a nucleoside disulfide, and only the second of a xylo-nucleoside. Structure elucidation of the disulfide was achieved by detailed spectroscopic analysis and comparison to synthetic model compounds. The antibacterial, antifungal, and anticancer properties of the disulfide are documented and the literature surrounding natural and synthetic thionucleosides is reviewed.
UR - http://www.scopus.com/inward/record.url?scp=77953723455&partnerID=8YFLogxK
U2 - 10.1071/CH09645
DO - 10.1071/CH09645
M3 - Article
AN - SCOPUS:77953723455
SN - 0004-9425
VL - 63
SP - 873
EP - 876
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 6
ER -