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  • Stuart L. Graham
2020
Open Access
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An intraocular pressure polygenic risk score stratifies multiple primary open-angle glaucoma parameters including treatment intensity

Qassim, A., Souzeau, E., Siggs, O. M., Hassall, M. M., Han, X., Griffiths, H. L., Frost, N. A., Vallabh, N. A., Kirwan, J. F., Menon, G., Cree, A. J., Galanopoulos, A., Agar, A., Healey, P. R., Graham, S. L., Landers, J., Casson, R. J., Gharahkhani, P., Willoughby, C. E., Hewitt, A. W. & 3 others, Lotery, A. J., MacGregor, S. & Craig, J. E., Jul 2020, In : Ophthalmology. 127, 7, p. 901-907 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation

Abbasi, M., Gupta, V. K., Chitranshi, N., Gupta, V. B., Mirzaei, M., Dheer, Y., Garthwaite, L., Zaw, T., Parton, R. G., You, Y. & Graham, S. L., Sep 2020, In : Molecular Neurobiology. 57, 9, p. 3759-3784 26 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Chronic demyelination exacerbates neuroaxonal loss in patients with MS with unilateral optic neuritis

You, Y., Barnett, M. H., Yiannikas, C., Parratt, J., Matthews, J., Graham, S. L. & Klistorner, A., 1 May 2020, In : Neurology(R) neuroimmunology & neuroinflammation. 7, 3, p. 1-10 10 p., e700.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: a prospective multi-site study

Qassim, A., Walland, M. J., Landers, J., Awadalla, M., Nguyen, T., Loh, J., Schulz, A. M., Ridge, B., Galanopoulos, A., Agar, A., Hewitt, A. W., Graham, S. L., Healey, P. R., Casson, R. J. & Craig, J. E., May 2020, In : Clinical and Experimental Ophthalmology. 48, 4, p. 442-449 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
File
1 Citation (Scopus)

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

Craig, J. E., Han, X., Qassim, A., Hassall, M., Cooke Bailey, J. N., Kinzy, T. G., Khawaja, A. P., An, J., Marshall, H., Gharahkhani, P., Igo, R. P., Graham, S. L., Healey, P. R., Ong, J. S., Zhou, T., Siggs, O., Law, M. H., Souzeau, E., Ridge, B., Hysi, P. G. & 41 others, Burdon, K. P., Mills, R. A., Landers, J., Ruddle, J. B., Agar, A., Galanopoulos, A., White, A. J. R., Willoughby, C. E., Andrew, N. H., Best, S., Vincent, A. L., Goldberg, I., Radford-Smith, G., Martin, N. G., Montgomery, G. W., Vitart, V., Hoehn, R., Wojciechowski, R., Jonas, J. B., Aung, T., Pasquale, L. R., Cree, A. J., Sivaprasad, S., Vallabh, N. A., NEIGHBORHOOD consortium, UK Biobank Eye and Vision Consortium, Viswanathan, A. C., Pasutto, F., Haines, J. L., Klaver, C. C. W., van Duijn, C. M., Casson, R. J., Foster, P. J., Khaw, P. T., Hammond, C. J., Mackey, D. A., Mitchell, P., Lotery, A. J., Wiggs, J. L., Hewitt, A. W. & MacGregor, S., Feb 2020, In : Nature Genetics. 52, p. 160-166 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Pressure dependency of retinal arterial pulse wave velocity in the rat

Rezaeian, M., Georgevsky, D., Golzan, S. M., Graham, S., Avolio, A. & Butlin, M., 1 Mar 2020, In : Artery Research. 26, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Downloads (Pure)
1 Citation (Scopus)

The association between retinal and central pulse wave velocity in the elderly

Rezaeian, M., Golzan, S. M., Avolio, A. P., Graham, S. & Butlin, M., Sep 2020, In : Artery Research. 26, 3, p. 148-153 6 p.

Research output: Contribution to journalArticle

Open Access
File
2019
Open Access
File
5 Citations (Scopus)
13 Downloads (Pure)

A novel method for retinal vessel segmentation and diameter measurement using high speed video

Rezaeian, M., Butlin, M., Golzan, S. M., Graham, S. L. & Avolio, A. P., 1 Jul 2019, 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE), p. 2781-2784 4 p. 8856879

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Association between BDNF Val66Met polymorphism and optic neuritis damage in neuromyelitis optica spectrum disorder

Shen, T., Gupta, V., Yiannikas, C., Klistorner, A., Graham, S. L. & You, Y., 19 Nov 2019, In : Frontiers in Neuroscience. 13, p. 1-6 6 p., 1236.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)

Bilateral optic atrophy from a silent occipital lesion

You, Y. & Graham, S. L., 1 Jul 2019, In : Ophthalmology. 126, 7, p. 979 1 p.

Research output: Contribution to journalComment/opinion

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Evidence of Müller glial dysfunction in patients with aquaporin-4 immunoglobulin G–positive neuromyelitis optica spectrum disorder

You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M. H., Fraser, C. L., Gillies, M., Graham, S. L. & Klistorner, A., 1 Jun 2019, In : Ophthalmology. 126, 6, p. 801-810 10 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
13 Downloads (Pure)

Lesion activity and chronic demyelination are the major determinants of brain atrophy in MS

Wang, C., Barnett, M. H., Yiannikas, C., Barton, J., Parratt, J., You, Y., Graham, S. L. & Klistorner, A., 1 Sep 2019, In : Neurology: Neuroimmunology and Neuroinflammation. 6, 5, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)

Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection

Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Macular ganglion cell–inner plexiform layer loss precedes peripapillary retinal nerve fiber layer loss in glaucoma with lower intraocular pressure

Marshall, H. N., Andrew, N. H., Hassall, M., Qassim, A., Souzeau, E., Ridge, B., Nguyen, T., Fitzgerald, J., Awadalla, M. S., Burdon, K. P., Healey, P. R., Agar, A., Galanopoulos, A., Hewitt, A. W., Graham, S. L., Landers, J., Casson, R. J. & Craig, J. E., 1 Aug 2019, In : Ophthalmology. 126, 8, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
4 Citations (Scopus)

Myocilin gene Gln368Ter variant penetrance and association with glaucoma in population-based and registry-based studies

Han, X., Souzeau, E., Ong, J-S., An, J., Siggs, O. M., Burdon, K. P., Best, S., Goldberg, I., Healey, P. R., Graham, S. L., Ruddle, J. B., Mills, R. A., Landers, J., Galanopoulos, A., White, A. J. R., Casson, R., Mackey, D. A., Hewitt, A. W., Gharahkhani, P., Craig, J. E. & 1 others, Macgregor, S., 1 Jan 2019, In : JAMA Ophthalmology. 137, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reply

You, Y., Graham, S. L. & Klistorner, A., 1 Aug 2019, In : Ophthalmology. 126, 8, p. e64-e65 2 p.

Research output: Contribution to journalLetter

Retinal neuroprotective function of Siponimod in a mouse model of experimental glaucoma

Basavarajappa, D., Klistorner, A., Chitranshi, N., Gupta, V. & Graham, S., Sep 2019, In : Multiple Sclerosis Journal. 25, 2 Supplement, p. 934-935 2 p., P1663.

Research output: Contribution to journalMeeting abstract

8 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
19 Downloads (Pure)
7 Citations (Scopus)
2018

A deep learning-based algorithm identifies glaucomatous discs using monoscopic fundus photographs

Liu, S., Graham, S. L., Schulz, A., Kalloniatis, M., Zangerl, B., Cai, W., Gao, Y., Chua, B., Klistorner, A. & You, Y., 15 Jul 2018, In : Ophthalmology Glaucoma. 1, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., Kang, J. H., Haines, J. L., Souzeau, E., Zhou, T., Siggs, O. M., Landers, J., Awadalla, M., Sharma, S., Mills, R. A., Ridge, B., Lynn, D., Casson, R., Graham, S. L., Goldberg, I. & 20 others, White, A., Healey, P. R., Grigg, J., Lawlor, M., Mitchell, P., Ruddle, J., Coote, M., Walland, M., Best, S., Vincent, A., Gale, J., Radfordsmith, G., Whiteman, D. C., Montgomery, G. W., Martin, N. G., MacKey, D. A., Wiggs, J. L., MacGregor, S., Craig, J. E. & The NEIGHBORHOOD consortium, 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 3124.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
9 Downloads (Pure)

Anterograde microstructural changes along the visual pathways in optic neuritis

You, Y., Wang, C., Liu, S., Graham, S. L. & Klistorner, A., Jan 2018, In : Investigative Ophthalmology and Visual Science. 59, 9, 1 p., 615.

Research output: Contribution to journalMeeting abstract

BDNF polymorphism: a review of its diagnostic and clinical relevance in neurodegenerative disorders

Shen, T., You, Y., Joseph, C., Mirzaei, M., Klistorner, A., Graham, S. L. & Gupta, V., 1 Jun 2018, In : Aging and Disease. 9, 3, p. 523-536 14 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
44 Downloads (Pure)
13 Citations (Scopus)

Carbohydrate ingestion induces differential autonomic dysregulation in normal-tension glaucoma and primary open angle glaucoma

Cao, L., Graham, S. L. & Pilowsky, P. M., 1 Jun 2018, In : PLoS ONE. 13, 6, p. 1-21 21 p., e0198432.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
14 Downloads (Pure)

Diffusivity in the core of chronic multiple sclerosis lesions

Klistorner, A., Wang, C., Yiannikas, C., Parratt, J., Barton, J., You, Y., Graham, S. L. & Barnett, M. H., 25 Apr 2018, In : PLoS ONE. 13, 4, p. 1-20 20 p., e0194142.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
4 Downloads (Pure)

DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma

Burdon, K. P., Awadalla, M. S., Mitchell, P., Wang, J. J., White, A., Keane, M. C., Souzeau, E., Graham, S. L., Goldberg, I., Healey, P. R., Landers, J., Mills, R. A. D., Best, S., Hewitt, A. W., Sharma, S. & Craig, J. E., 4 Mar 2018, In : Ophthalmic Genetics. 39, 2, p. 221-227 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Evidence of progressive tissue loss in the core of chronic MS lesions: a longitudinal DTI study

Klistorner, A., Wang, C., Yiannikas, C., Parratt, J., Dwyer, M., Barton, J., Graham, S. L., You, Y., Liu, S. & Barnett, M. H., 2018, In : NeuroImage: Clinical. 17, p. 1028-1035 8 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
22 Downloads (Pure)

FTY720 promotes cellular pathways involved in myelination and anti-oxidant system in the brain cortex

Mirzaei, M., Gupta, V., Klistorner, A. & Graham, SL., 10 Apr 2018, In : Neurology. 90, 15 Supplement, P1.411.

Research output: Contribution to journalMeeting abstract

Open Access

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

MacGregor, S., Ong, J-S., An, J., Han, X., Zhou, T., Siggs, O. M., Law, M. H., Souzeau, E., Sharma, S., Lynn, D. J., Beesley, J., Sheldrick, B., Mills, R. A., Landers, J., Ruddle, J. B., Graham, S. L., Healey, P. R., White, A. J. R., Casson, R. J., Best, S. & 12 others, Grigg, J. R., Goldberg, I., Powell, J. E., Whiteman, D. C., Radford-Smith, G. L., Martin, N. G., Montgomery, G. W., Burdon, K. P., Mackey, D. A., Gharahkhani, P., Craig, J. E. & Hewitt, A. W., 1 Aug 2018, In : Nature Genetics. 50, 8, p. 1067-1071 5 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Glaucoma pathogenesis and neurotrophins: focus on the molecular and genetic basis for therapeutic prospects

Chitranshi, N., Dheer, Y., Abbasi, M., You, Y., Graham, S. L. & Gupta, V., 2018, In : Current Neuropharmacology. 16, 7, p. 1018 - 1035 18 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Monitoring of optic nerve function in Neurofibromatosis 2 children with optic nerve sheath meningiomas using multifocal visual evoked potentials

Jayanetti, V., Klistorner, A. I., Graham, S. L., Dexter, M., Flaherty, M. P., Jones, K., Billson, F. A., Wilson, M., North, K., Grigg, J. R. & Fraser, C. L., 1 Apr 2018, In : Journal of Clinical Neuroscience. 50, p. 262-267 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pathophysiological basis of low contrast visual acuity loss in multiple sclerosis

Triplett, J. D., Yiannikas, C., Barnett, M. H., Parratt, J., Barton, J., Graham, S. L., You, Y. & Klistorner, A., Dec 2018, In : Annals of Clinical and Translational Neurology. 5, 12, p. 1505-1512 8 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
9 Downloads (Pure)

Performance of iPad-based threshold perimetry in glaucoma and controls

Schulz, A. M., Graham, E. C., You, Y., Klistorner, A. & Graham, S. L., Jun 2018, In : Clinical and Experimental Ophthalmology. 46, 4, p. 346-355 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

Awadalla, M. S., Fitzgerald, J., Andrew, N. H., Zhou, T., Marshall, H., Qassim, A., Hassall, M., Casson, R. J., Graham, S. L., Healey, P. R., Agar, A., Galanopoulos, A., Phipps, S., Chappell, A., Landers, J. & Craig, J. E., 5 Dec 2018, In : PLoS ONE. 13, 12, p. 1-9 9 p., e0206684.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
4 Downloads (Pure)

Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS

You, Y., Graham, E. C., Shen, T., Yiannikas, C., Parratt, J., Gupta, V., Barton, J., Dwyer, M., Barnett, M. H., Fraser, C. L., Graham, S. L. & Klistorner, A., 1 Jan 2018, In : Neurology: Neuroimmunology and Neuroinflammation. 5, 1, p. 1-9 9 p., e427.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
3352 Downloads (Pure)
Open Access
File
13 Citations (Scopus)
10 Downloads (Pure)
2017

Afferent visual pathways in multiple sclerosis: a review

Graham, S. L. & Klistorner, A., Jan 2017, In : Clinical and Experimental Ophthalmology. 45, 1, p. 62-72 11 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Mirzaei, M., Gupta, V. B., Chick, J. M., Greco, T. M., Wu, Y., Chitranshi, N., Wall, R. V., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Salekdeh, G. H., Haynes, P. A., Molloy, M. P., Martins, R., Cristea, I. M., Gygi, S. P. & 2 others, Graham, S. L. & Gupta, V. K., 4 Oct 2017, In : Scientific Reports. 7, 1, p. 1-16 16 p., 12685.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
26 Downloads (Pure)