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  • Gilles Guillemin

3Rs-based optimization of mice behavioral testing: the habituation/dishabituation olfactory test

Oummadi, A., Meyer-Dilhet, G., Béry, A., Aubert, A., Barone, P., Mortaud, S., Guillemin, G. J., Menuet, A. & Laugeray, A., 15 Feb 2020, In : Journal of Neuroscience Methods. 332, p. 1-15 15 p., 108550.

Research output: Contribution to journalArticle

Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers

Puccetti, P., Fallarino, F., Italiano, A., Soubeyran, I., MacGrogan, G., Debled, M., Velasco, V., Bodet, D., Eimer, S., Veldhoen, M., Prendergast, G. C., Platten, M., Bessede, A. & Guillemin, G. J., 16 Apr 2015, In : PLoS ONE. 10, 4, p. 1-9 9 p., e0122046.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 30 May 2015, In : Journal of Neuroinflammation. 12, p. 1-17 17 p., 110.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
5 Downloads (Pure)

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue

Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B. & Guillemin, G. J., 27 Jul 2012, In : PLoS ONE. 7, 7, p. 1-9 9 p., e42357.

Research output: Contribution to journalArticle

Open Access
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226 Citations (Scopus)
5 Downloads (Pure)

Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats

Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T., Poljak, A. & Grant, R., 2011, In : PLoS ONE. 6, 4, p. 1-18 18 p., e19194.

Research output: Contribution to journalArticle

Open Access
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319 Citations (Scopus)
16 Downloads (Pure)

Almonds and brain functionality

Essa, M. M., Subash, S., Parvathy, S., Meera, A., Guillemin, G. J., Memon, M. A. & Manivasagam, T., 2014, Food and Brain Health. Essa, M. M., Memon, M. A. & Akbar, M. (eds.). New York: Nova Science Publishers, p. 75-84 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alpha-synuclein transmission and mitochondrial toxicity in primary human foetal enteric neurons in vitro

Braidy, N., Gai, W. P., Xu, Y. H., Sachdev, P., Guillemin, G. J., Jiang, X. M., Ballard, J. W. O., Horan, M. P., Fang, Z. M., Chong, B. H. & Chan, D. K. Y., Feb 2014, In : Neurotoxicity Research. 25, 2, p. 170-182 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: a pilot study

Chatterjee, P., Goozee, K., Lim, C. K., James, I., Shen, K., Jacobs, K. R., Sohrabi, H. R., Shah, T., Asih, P. R., Dave, P., ManYan, C., Taddei, K., Lovejoy, D. B., Chung, R., Guillemin, G. J. & Martins, R. N., 1 Dec 2018, In : Scientific Reports. 8, 1, p. 1-10 10 p., 8008.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
13 Downloads (Pure)

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

Lim, C. K., Essa, M. M., de Paula Martins, R., Lovejoy, D. B., Bilgin, A. A., Waly, M. I., Al-Farsi, Y. M., Al-Sharbati, M., Al-Shaffae, M. A. & Guillemin, G. J., 1 Jun 2016, In : Autism Research. 9, 6, p. 621-631 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Amelioration of aluminum maltolate-induced inflammation and endoplasmic reticulum stress-mediated apoptosis by tannoid principles of Emblica officinalis in neuronal cellular model

Dhivya Bharathi, M., Justin-Thenmozhi, A., Manivasagam, T., Ahmad Rather, M., Saravana Babu, C., Mohamed Essa, M. & Guillemin, G. J., 1 Feb 2019, In : Neurotoxicity Research. 35, 2, p. 318-330 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

An effective, low-cost method for achieving and maintaining hypoxia during cell culture studies

Bakmiwewa, S. M., Heng, B., Guillemin, G. J., Ball, H. J. & Hunt, N. H., 1 Oct 2015, In : BioTechniques. 59, 4, p. 223-229 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., Jugold, M., Guillemin, G. J., Miller, C. L., Lutz, C., Radlwimmer, B., Lehmann, I., Von Deimling, A., Wick, W. & Platten, M., 13 Oct 2011, In : Nature. 478, 7368, p. 197-203 7 p.

Research output: Contribution to journalArticle

875 Citations (Scopus)

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

Brundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., Postolache, T. T., Traskman-Bendz, L., Guillemin, G. J. & Erhardt, S., 2 Aug 2016, In : Translational Psychiatry. 6, p. 1-9 9 p., e865.

Research output: Contribution to journalArticle

Open Access
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57 Citations (Scopus)
12 Downloads (Pure)

An in vitro evidence for caffeic acid, rosmarinic acid and trans cinnamic acid as a skin protectant against γ-radiation

Hakkim, F. L., Miura, M., Matsuda, N., Alharassi, A. S., Guillemin, G., Yamauchi, M., Arivazhagan, G. & Song, H., 2014, In : International Journal of Low Radiation. 9, 4, p. 305-316 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Antiamyloidogenic effect of dates grown in Oman with reference to their possible protection against Alzheimer's disease

Essa, M. M., Guillemin, G. J., Al-Adawi, S., Al-Asmi, A., Vaishnav, R., Ramachandiran, N. & Memon, M. A., 2012, Dates: production, processing, food, and medicinal values. Manickavasagan, A., Mohamed Essa, M. & Sukumar, E. (eds.). Boca Raton, FL: CRC Press, Taylor & Francis Group, p. 397-403 7 p. (Medicinal and aromatic plants - industrial profiles; vol. 50).

Research output: Chapter in Book/Report/Conference proceedingChapter

Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton

Dale, R. C., Tantsis, E. M., Merheb, V., Kumaran, R. Y. A., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D. R., Wienholt, L. A., Prelog, K., Clark, D. R., Guillemin, G. J., Lim, C. K., Mathey, E. K. & Brilot, F., 24 Apr 2014, In : Neurology: Neuroimmunology and Neuroinflammation. 1, 1, p. 1-12 12 p., e12.

Research output: Contribution to journalArticle

Open Access
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83 Citations (Scopus)
67 Downloads (Pure)

Antibodies to myelin oligodendrocyte glycoprotein have a demyelination phenotype in children and affect oligodendrocyte cytoskeleton

Dale, R. C., Tantsis, E. M., Merheb, V., Kumaran, R. A., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D. R., Wienholt, L. A., Prelog, K., Clark, D. R., Guillemin, G. J., Lim, C. K., Mathey, E. K. & Brilot, F., 15 Oct 2014, In : Journal of Neuroimmunology. 275, 1-2, p. 17-17 1 p.

Research output: Contribution to journalMeeting abstract

Antioxidant therapies in attention deficit hyperactivity disorder

Moghadas, M., Essa, M. M., Ba-Omar, T., Al-Shehi, A., Qoronfleh, M. W., Eltayeb, E. A., Guillemin, G. J., Manivasagam, T., Justin-Thenmozhi, A., Al-Bulushi, B. S., Al-Adawi, S. & Edalatmanesh, M. A., 1 Jan 2019, In : Frontiers in bioscience (Landmark edition). 24, 2, p. 313-333 21 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Application of N-methyl-D-aspartate receptor nanopore in screening ligand molecules

Li, S-P., Zhang, Y-C., Hu, F-Z., Sabaretnam, T., Guillemin, G. J. & Zou, A-H., 1 Aug 2020, In : Bioelectrochemistry. 134, p. 1-8 8 p., 107534.

Research output: Contribution to journalArticle

Are herbal medicines effective in the treatment of ischemic stroke? A systematic review of human-controlled clinical trials

Delshad, E., Doosti, H., Guillemin, G., Naghedi-Baghdar, H., Ayati, Z., Kaboli Farshchi, M., Javan, R. & Yousefi, M., 2019, In : Herbal Medicines Journal . 4, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

A role for glial-associated kynurenine pathway activation in modulating neuronal outgrowth and complexity

O'Farrell, K., Lim, E., Guillemin, G. J. & Harkin, A., Sep 2015, In : European Neuropsychopharmacology. 25, p. S206-S207 2 p.

Research output: Contribution to journalMeeting abstract

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

Bay-Richter, C., Linderholm, K. R., Lim, C. K., Samuelsson, M., Träskman-Bendz, L., Guillemin, G. J., Erhardt, S. & Brundin, L., 1 Jan 2015, In : Brain, Behavior, and Immunity. 43, p. 110-117 8 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Bessede, A., Gargaro, M., Pallotta, M. T., Matino, D., Servillo, G., Brunacci, C., Bicciato, S., Mazza, E. M. C., Macchiarulo, A., Vacca, C., Iannitti, R., Tissi, L., Volpi, C., Belladonna, M. L., Orabona, C., Bianchi, R., Lanz, T. V., Platten, M., Della Fazia, M. A., Piobbico, D. & 18 others, Zelante, T., Funakoshi, H., Nakamura, T., Gilot, D., Denison, M. S., Guillemin, G. J., Duhadaway, J. B., Prendergast, G. C., Metz, R., Geffard, M., Boon, L., Pirro, M., Iorio, A., Veyret, B., Romani, L., Grohmann, U., Fallarino, F. & Puccetti, P., 2014, In : Nature. 511, 7508, p. 184-190 7 p.

Research output: Contribution to journalArticle

316 Citations (Scopus)

Asiatic acid attenuated aluminum chloride-induced tau pathology, oxidative stress and apoptosis via AKT/GSK-3β signaling pathway in Wistar rats

Ahmad Rather, M., Justin-Thenmozhi, A., Manivasagam, T., Saravanababu, C., Guillemin, G. J. & Essa, M. M., 15 May 2019, In : Neurotoxicity Research. 35, 4, p. 955-968 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Autism and gut–brain axis: role of probiotics

Chidambaram, S. B., Tuladhar, S., Bhat, A., Mahalakshmi, A. M., Ray, B., Essa, M. M., Bishir, M., Bolla, S. R., Nanjaiah, N. D., Guillemin, G. J. & Qoronfleh, M. W., 1 Jan 2020, Personalized food intervention and therapy for autism spectrum disorder management. Essa, M. M. & Qoronfleh, M. W. (eds.). Switzerland: Springer, p. 587-600 14 p. (Advances in Neurobiology; vol. 24).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?

Lennon, M. J., Jones, S. P., Lovelace, M. D., Guillemin, G. J. & Brew, B. J., 1 Feb 2016, In : Neurotoxicity Research. 29, 2, p. 201-207 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Bcl11b-A critical neurodevelopmental transcription factor-roles in health and disease

Lennon, M. J., Jones, S. P., Lovelace, M. D., Guillemin, G. J. & Brew, B. J., 29 Mar 2017, In : Frontiers in Cellular Neuroscience. 11, p. 1-7 7 p., 89.

Research output: Contribution to journalReview article

Open Access
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11 Citations (Scopus)
4 Downloads (Pure)

Beneficial effects of coating alginate microcapsules with macromolecular heparin conjugates-In vitro and in vivo study

Vaithilingam, V., Kollarikova, G., Qi, M., Larsson, R., Lacik, I., Formo, K., Marchese, E., Oberholzer, J., Guillemin, G. J. & Tuch, B. E., 1 Jan 2014, In : Tissue Engineering - Part A. 20, 1-2, p. 324-334 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Blueberries and health benefits

Vijayan, R. K., Essa, M. M., Al-Rawahi, A. S., Guillemin, G. J., Selvaraju, S. & Memon, M. A., 2013, Food as medicine. Essa, M. M. & Memon, M. A. (eds.). New York: Nova Science Publishers, p. 17-35 19 p. (Food science and technology).

Research output: Chapter in Book/Report/Conference proceedingChapter

BMAA and Neurodegenerative Illness

Cox, P. A., Kostrzewa, R. M. & Guillemin, G. J., Jan 2018, In : Neurotoxicity Research. 33, 1, p. 178–183 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Boswellia gum resin and essential oils: potential health benefits - an evidence based review

Rashan, L., Hakkim, F. L., Idrees, M., Essa, M. M., Velusamy, T., Al-Baloshi, M., Al-Balushi, B. S., Al Jabri, A., Al-Rizeiqi, M. H., Guillemin, G. & Abdo Hasson, S. S. A., 1 Apr 2019, In : International Journal of Nutrition, Pharmacology, Neurological Diseases. 9, 2, p. 53-71 19 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Brain health benefits of Moringa oleifera

Essa, M. M., Subash, S., Parvathy, S., Meera, A., Guillemin, G. J., Memon, M. A. & Manivasagam, T., 2014, Food and Brain Health. Essa, M. M., Memon, M. A. & Akbar, M. (eds.). New York: Nova Science Publishers, p. 113-118 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carrots: nutritional and health benefits

Vijayan, R. K., Khan, A. J., Essa, M. M., Al-Rawahi, A. S., Guillemin, G. J. & Selvaraju, S., 2013, Food as medicine. Essa, M. M. & Memon, M. A. (eds.). New York: Nova Science Publishers, p. 243-258 16 p. (Food science and technology series).

Research output: Chapter in Book/Report/Conference proceedingChapter

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Williams, K. L., Topp, S., Yang, S., Smith, B., Fifita, J. A., Warraich, S. T., Zhang, K. Y., Farrawell, N., Vance, C., Hu, X., Chesi, A., Leblond, C. S., Lee, A., Rayner, S. L., Sundaramoorthy, V., Dobson-Stone, C., Molloy, M. P., Van Blitterswijk, M., Dickson, D. W., Petersen, R. C. & 48 others, Graff-Radford, N. R., Boeve, B. F., Murray, M. E., Pottier, C., Don, E., Winnick, C., McCann, E. P., Hogan, A., Daoud, H., Levert, A., Dion, P. A., Mitsui, J., Ishiura, H., Takahashi, Y., Goto, J., Kost, J., Gellera, C., Gkazi, A. S., Miller, J., Stockton, J., Brooks, W. S., Boundy, K., Polak, M., Muñoz-Blanco, J. L., Esteban-Pérez, J., Rábano, A., Hardiman, O., Morrison, K. E., Ticozzi, N., Silani, V., De Belleroche, J., Glass, J. D., Kwok, J. B. J., Guillemin, G. J., Chung, R. S., Tsuji, S., Brown, R. H., García-Redondo, A., Rademakers, R., Landers, J. E., Gitler, A. D., Rouleau, G. A., Cole, N. J., Yerbury, J. J., Atkin, J. D., Shaw, C. E., Nicholson, G. A. & Blair, I. P., 15 Apr 2016, In : Nature Communications. 7, p. 1-8 8 p., 11253.

Research output: Contribution to journalArticle

Open Access
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83 Citations (Scopus)
15 Downloads (Pure)

Central kynurenine pathway shift with age in women

De Bie, J., Guest, J., Guillemin, G. J. & Grant, R., 1 Mar 2016, In : Journal of Neurochemistry. 136, 5, p. 995-1003 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons

Braidy, N., Brew, B. J., Inestrosa, N. C., Chung, R., Sachdev, P. & Guillemin, G. J., 1 Sep 2014, In : Metabolic brain disease. 29, 3, p. 873-883 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats

Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T. & Grant, R., Nov 2011, In : FEBS Journal. 278, 22, p. 4425-4434 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Chapter 20: Role of the kynurenine pathway in stem cell biology

Jones, S. P., Guillemin, G. J. & Brew, B. J., 1 Jan 2015, Targeting the Broadly Pathogenic Kynurenine Pathway. Mittal, S. (ed.). Cham: Springer, Springer Nature, p. 257-272 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes

Sheipouri, D., Grant, R., Bustamante, S., Lovejoy, D., Guillemin, G. J. & Braidy, N., 1 Jun 2015, In : Journal of Cellular Biochemistry. 116, 6, p. 903-922 20 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Characterization of functional polymorphisms and glucocorticoid-responsive elements in the promoter of TDO2, a candidate gene for ethanol-induced behavioural disorders

Soichot, M., Vaast, A., Vignau, J., Guillemin, G. J., Lhermitte, M., Broly, F. & Allorge, D., Jul 2013, In : Alcohol and Alcoholism. 48, 4, p. 415-425 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Characterization of the Kynurenine pathway and quinolinic acid production in macaque macrophages

Lim, C. K., Yap, M. M. C., Kent, S. J., Gras, G., Samah, B., Batten, J. C., De Rose, R., Heng, B., Brew, B. J. & Guillemin, G. J., 2013, In : International Journal of Tryptophan Research. 6, p. 7-19 13 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
20 Downloads (Pure)

Characterization of the Kynurenine Pathway in CD8+ Human Primary Monocyte-Derived Dendritic Cells

Braidy, N., Rossez, H., Lim, C. K., Jugder, B. E., Brew, B. J. & Guillemin, G. J., 1 Nov 2016, In : Neurotoxicity Research. 30, 4, p. 620-632 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Characterization of the kynurenine pathway in NSC-34 cell line: Implications for amyotrophic lateral sclerosis

Chen, Y., Brew, B. J. & Guillemin, G. J., Sep 2011, In : Journal of Neurochemistry. 118, 5, p. 816-825 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos

Aksoy, Y. A., Nguyen, D. T., Chow, S., Chung, R. S., Guillemin, G. J., Cole, N. J. & Hesselson, D., 23 May 2019, In : Communications Biology. 2, p. 1-9 9 p., 198.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
32 Downloads (Pure)

Chronic mild stress augments MPTP induced neurotoxicity in a murine model of Parkinson's disease

Janakiraman, U., Manivasagam, T., Thenmozhi, A. J., Dhanalakshmi, C., Essa, M. M., Song, B. J. & Guillemin, G. J., 1 May 2017, In : Physiology and Behavior. 173, p. 132-143 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Chronic treatment with the IDO1 inhibitor 1-methyl-D-tryptophan minimizes the behavioural and biochemical abnormalities induced by unpredictable chronic mild stress in mice - Comparison with fluoxetine

Laugeray, A., Launay, J. M., Callebert, J., Mutlu, O., Guillemin, G. J., Belzung, C. & Barone, P. R., 9 Nov 2016, In : PLoS ONE. 11, 11, p. 1-17 17 p., e0164337.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
12 Downloads (Pure)

Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP+ intoxicated human neuroblastoma cells (SH-SY5Y)

Chidambaram, S. B., Bhat, A., Ray, B., Sugumar, M., Muthukumar, S. P., Manivasagam, T., Justin Thenmozhi, A., Essa, M. M., Guillemin, G. J. & Sakharkar, M. K., Jun 2020, In : Nutritional Neuroscience. 23, 6, p. 471-480 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Connecting inflammation with glutamate agonism in suicidality

Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J. & Brundin, L., Apr 2013, In : Neuropsychopharmacology. 38, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

Open Access
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183 Citations (Scopus)
3 Downloads (Pure)

Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease

Subash, S., Essa, M. M., Braidy, N., Al-Jabri, A., Vaishnav, R., Al-Adawi, S., Al-Asmi, A. & Guillemin, G. J., 12 Dec 2016, In : Nutritional Neuroscience. 19, 10, p. 475-483 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)