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  • Richard Kefford
2020

Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial

Dummer, R., Brase, J. C., Garrett, J., Campbell, C. D., Gasal, E., Squires, M., Gusenleitner, D., Santinami, M., Atkinson, V., Mandalà, M., Chiarion-Sileni, V., Flaherty, K., Larkin, J., Robert, C., Kefford, R., Kirkwood, J. M., Hauschild, A., Schadendorf, D. & Long, G. V., 1 Mar 2020, In : The Lancet Oncology. 21, 3, p. 358-372 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
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Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib monotherapy: analysis from phase 2 and 3 clinical trials

Hauschild, A., Ascierto, P. A., Schadendorf, D., Grob, J. J., Ribas, A., Kiecker, F., Dutriaux, C., Demidov, L. V., Lebbé, C., Rutkowski, P., Blank, C. U., Gutzmer, R., Millward, M., Kefford, R., Haas, T., D'Amelio, A., Gasal, E., Mookerjee, B. & Chapman, P. B., 1 Jan 2020, In : European Journal of Cancer. 125, p. 114-120 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Analysis of the whole-exome sequencing of tumor and circulating tumor DNA in metastatic melanoma

Diefenbach, R. J., Lee, J. H., Strbenac, D., Yang, J. Y. H., Menzies, A. M., Carlino, M. S., Long, G. V., Spillane, A. J., Stretch, J. R., Saw, R. P. M., Thompson, J. F., Ch'ng, S., Scolyer, R. A., Kefford, R. F. & Rizos, H., 29 Nov 2019, In : Cancers. 11, 12, p. 1-14 14 p., 1905.

Research output: Contribution to journalArticle

Open Access
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Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure

Cust, A. E., Drummond, M., Bishop, D. T., Azizi, L., Schmid, H., Jenkins, M. A., Hopper, J. L., Armstrong, B. K., Aitken, J. F., Kefford, R. F., Giles, G. G., Demenais, F., Goldstein, A. M., Barrett, J. H., Kanetsky, P. A., Elder, D. E., Mann, G. J. & Newton-Bishop, J. A., Oct 2019, In : Journal of the European Academy of Dermatology and Venereology. 33, 10, p. 1874-1885 12 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
2 Downloads (Pure)

bcGST: an interactive bias-correction method to identify over-represented gene-sets in boutique arrays

Wang, K. Y. X., Menzies, A. M., Silva, I. P., Wilmott, J. S., Yan, Y., Wongchenko, M., Kefford, R. F., Scolyer, R. A., Long, G. V., Tarr, G., Mueller, S. & Yang, J. Y. H., 15 Apr 2019, In : Bioinformatics. 35, 8, p. 1350-1357 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Circulating cytokines predict immune-related toxicity in melanoma patients receiving anti-PD-1 based immunotherapy

Lim, S. Y., Lee, J. H., Nur Gide, T., Menzies, A. M., Guminski, A., Carlino, M. S., Breen, E., Yang, J. Y. H., Ghazanfar, S., Kefford, R. F., Scolyer, R. A., Long, G. V. & Rizos, H., Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Development and validation of a targeted gene sequencing panel for application to disparate cancers

McCabe, M. J., Gauthier, M-E. A., Chan, C-L., Thompson, T. J., De Sousa, S. M. C., Puttick, C., Grady, J. P., Gayevskiy, V., Tao, J., Ying, K., Cipponi, A., Deng, N., Swarbrick, A., Thomas, M. L., kConFab, Lord, R. V., Johns, A. L., Kohonen-Corish, M., O’Toole, S. A., Clark, J. & 5 others, Mueller, S. A., Gupta, R., McCormack, A. I., Dinger, M. E. & Cowley, M. J., 1 Dec 2019, In : Scientific Reports. 9, 1, 16 p., 17052.

Research output: Contribution to journalArticle

Open Access
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Distinct molecular profiles and immunotherapy treatment outcomes of V600E and V600K BRAF-mutant melanoma

da Silva, I. P., Wang, K. Y. X., Wilmott, J. S., Holst, J., Carlino, M. S., Park, J. J., Quek, C., Wongchenko, M., Yan, Y., Mann, G., Johnson, D. B., McQuade, J. L., Rai, R., Kefford, R. F., Rizos, H., Scolyer, R. A., Yang, J. Y. H., Long, G. V. & Menzies, A. M., 15 Feb 2019, In : Clinical Cancer Research. 25, 4, p. 1272-1279 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001

Hamid, O., Robert, C., Daud, A., Hodi, F. S., Hwu, W. J., Kefford, R., Wolchok, J. D., Hersey, P., Joseph, R., Weber, J. S., Dronca, R., Mitchell, T. C., Patnaik, A., Zarour, H. M., Joshua, A. M., Zhao, Q., Jensen, E., Ahsan, S., Ibrahim, N. & Ribas, A., 1 Apr 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 4, p. 582-588 7 p.

Research output: Contribution to journalArticle

Open Access
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39 Citations (Scopus)
15 Downloads (Pure)

Homologous recombination DNA repair defects in PALB2-associated breast cancers

Li, A., Geyer, F. C., Blecua, P., Lee, J. Y., Selenica, P., Brown, D. N., Pareja, F., Lee, S. S. K., Kumar, R., Rivera, B., Bi, R., Piscuoglio, S., Wen, H. Y., Lozada, J. R., Gularte-Mérida, R., Cavallone, L., kConFab Investigators, Rezoug, Z., Nguyen-Dumont, T., Peterlongo, P. & 19 others, Tondini, C., Terkelsen, T., Rønlund, K., Boonen, S. E., Mannerma, A., Winqvist, R., Janatova, M., Rajadurai, P., Xia, B., Norton, L., Robson, M. E., Ng, P-S., Looi, L. M., Southey, M. C., Weigelt, B., Soo-Hwang, T., Tischkowitz, M., Foulkes, W. D. & Reis-Filho, J. S., 23 Nov 2019, In : npj Breast Cancer. 5, 1, p. 1-14 14 p., 23.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
1 Downloads (Pure)

Hypermethylation of circulating free DNA in cutaneous melanoma

Diefenbach, R. J., Lee, J. H., Chandler, D., Wang, Y., Pflueger, C., Long, G. V., Scolyer, R. A., Carlino, M. S., Menzies, A. M., Kefford, R. F. & Rizos, H., 25 Nov 2019, In : Applied Sciences. 9, 23, p. 1-17 17 p., 5074.

Research output: Contribution to journalArticle

Open Access
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1 Downloads (Pure)

Neoadjuvant dabrafenib combined with trametinib for resectable, stage IIIB–C, BRAFV600 mutation-positive melanoma (NeoCombi): a single-arm, open-label, single-centre, phase 2 trial

Long, G. V., Saw, R. P. M., Lo, S., Nieweg, O. E., Shannon, K. F., Gonzalez, M., Guminski, A., Lee, J. H., Lee, H., Ferguson, P. M., Rawson, R. V., Wilmott, J. S., Thompson, J. F., Kefford, R. F., Ch'ng, S., Stretch, J. R., Emmett, L., Kapoor, R., Rizos, H., Spillane, A. J. & 2 others, Scolyer, R. A. & Menzies, A. M., 1 Jul 2019, In : The Lancet Oncology. 20, 7, p. 961-971 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAF V600E or BRAF V600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised, placebo-controlled, phase 3 trial

Schadendorf, D., Hauschild, A., Santinami, M., Atkinson, V., Mandalà, M., Chiarion-Sileni, V., Larkin, J., Nyakas, M., Dutriaux, C., Haydon, A., Robert, C., Mortier, L., Lesimple, T., Plummer, R., Schachter, J., Dasgupta, K., Manson, S., Koruth, R., Mookerjee, B., Kefford, R. & 3 others, Dummer, R., Kirkwood, J. M. & Long, G. V., 1 May 2019, In : The Lancet Oncology. 20, 5, p. 701-710 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Pneumocystis jirovecii in a patient on dose-dense chemotherapy for early breast cancer

Khoo, C., Gilchrist, J., Williamson, J. P., Paul, M. & Kefford, R., Oct 2019, In : Respirology Case Reports. 7, 7, p. 1-4 4 p., e00459.

Research output: Contribution to journalArticle

Open Access
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8 Downloads (Pure)

Pre-operative ctDNA predicts survival in high-risk stage III cutaneous melanoma patients

Lee, J. H., Saw, R. P., Thompson, J. F., Lo, S., Spillane, A. J., Shannon, K. F., Stretch, J. R., Howle, J., Menzies, A. M., Carlino, M. S., Kefford, R. F., Long, G. V., Scolyer, R. A. & Rizos, H., 1 May 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 5, p. 815-822 8 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
9 Downloads (Pure)

Reply to E. Hindié and K.R. Hess

Long, G. V., Dummer, R., Schadendorf, D., Santinami, M., Atkinson, V., Mandalà, M., Chiarion-Sileni, V., Larkin, J., Nyakas, M., Dutriaux, C., Haydon, A., Robert, C., Mortier, L., Schachter, J., Lesimple, T., Plummer, R., Dasgupta, K., Haas, T., Shilkrut, M., Gasal, E. & 3 others, Kefford, R., Kirkwood, J. M. & Hauschild, A., 20 May 2019, In : Journal of Clinical Oncology. 37, 15, p. 1356-1358 3 p.

Research output: Contribution to journalLetter

Targeted therapy in advanced melanoma with rare BRAF mutations

Menzer, C., Menzies, A. M., Carlino, M. S., Reijers, I., Groen, E. J., Eigentler, T., de Groot, J. W. B., van der Veldt, A. A. M., Johnson, D. B., Meiss, F., Schlaak, M., Schilling, B., Westgeest, H. M., Gutzmer, R., Pföhler, C., Meier, F., Zimmer, L., Suijkerbuijk, K. P. M., Haalck, T., Thoms, K. M. & 9 others, Herbschleb, K., Leichsenring, J., Menzer, A., Kopp-Schneider, A., Long, G. V., Kefford, R., Enk, A., Blank, C. U. & Hassel, J. C., 20 Nov 2019, In : Journal of Clinical Oncology. 37, 33, p. 3142-3151 21 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Figlioli, G., Bogliolo, M., Catucci, I., Caleca, L., Lasheras, S. V., Pujol, R., Kiiski, J. I., Muranen, T. A., Barnes, D. R., Dennis, J., Michailidou, K., Bolla, M. K., Leslie, G., Aalfs, C. M., ABCTB Investigators, Adank, M. A., Adlard, J., Agata, S., Cadoo, K., Agnarsson, B. A. & 261 others, Ahearn, T., Aittomäki, K., Ambrosone, C. B., Andrews, L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Arun, B. K., Asseryanis, E., Auber, B., Auvinen, P., Azzollini, J., Balmaña, J., Barkardottir, R. B., Barrowdale, D., Barwell, J., Beane Freeman, L. E., Beauparlant, C. J., Beckmann, M. W., Behrens, S., Benitez, J., Berger, R., Bermisheva, M., Blanco, A. M., Blomqvist, C., Bogdanova, N. V., Bojesen, A., Bojesen, S. E., Bonanni, B., Borg, A., Brady, A. F., Brauch, H., Brenner, H., Brüning, T., Burwinkel, B., Buys, S. S., Caldés, T., Caliebe, A., Caligo, M. A., Campa, D., Campbell, I. G., Canzian, F., Castelao, J. E., Chang-Claude, J., Chanock, S. J., Claes, K. B. M., Clarke, C. L., Collavoli, A., Conner, T. A., Cox, D. G., Cybulski, C., Czene, K., Daly, M. B., de la Hoya, M., Devilee, P., Diez, O., Ding, Y. C., Dite, G. S., Ditsch, N., Domchek, S. M., Dorfling, C. M., dos-Santos-Silva, I., Durda, K., Dwek, M., Eccles, D. M., Ekici, A. B., Eliassen, A. H., Ellberg, C., Eriksson, M., Evans, D. G., Fasching, P. A., Figueroa, J., Flyger, H., Foulkes, W. D., Friebel, T. M., Friedman, E., Gabrielson, M., Gaddam, P., Gago-Dominguez, M., Gao, C., Gapstur, S. M., Garber, J., García-Closas, M., García-Sáenz, J. A., Gaudet, M. M., Gayther, S. A., GEMO Study Collaborators, Giles, G. G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., Guénel, P., Gutierrez-Barrera, A. M., Haeberle, L., Haiman, C. A., Håkansson, N., Hall, P., Hamann, U., Harrington, P. A., Hein, A., Heyworth, J., Hillemanns, P., Hollestelle, A., Hopper, J. L., Hosgood, H. D., Howell, A., Hu, C., Hulick, P. J., Hunter, D. J., Imyanitov, E. N., kConFab, Heiniger, L., Fenton, G., Issacs, C., Jakimovska, M., Jakubowska, A., James, P., Janavicius, R., Janni, W., John, E. M., Jones, M. E., Jung, A., Kaaks, R., Karlan, B. Y., Khusnutdinova, E., Kitahara, C. M., Konstantopoulou, I., Koutros, S., Kraft, P., Lambrects, D., Lazaro, C., Marchand, L. L., Lester, J., Lesueur, F., Lilyquist, J., Loud, J. T., Lu, K. H., Luben, R. N., Lubiński, J., Mannermaa, A., Manoochehri, M., Manoukian, S., Margolin, S., Martens, J. W. M., Maurer, T., Mavroudis, D., Mebirouk, N., Meindl, A., Menon, U., Miller, A., Montagna, M., Nathanson, K. L., Neuhausen, S. L., Newman, W. G., Nguyen-Dumont, T., Nielsen, F. C., Nielsen, S., Nikitina-Zake, L., Offit, K., Olah, E., Olopade, O. I., Olshan, A. F., Olson, J. E., Olsson, H., Osorio, A., Ottini, L., Peissel, B., Peixoto, A., Peto, J., Plaseska-Karanfilska, D., Pocza, T., Presneau, N., Pujana, M. A., Punie, K., Rack, B., Rantala, J., Rashid, M. U., Rau-Murthy, R., Rennert, G., Lejbkowicz, F., Rhenius, V., Romero, A., Rookus, M. A., Ross, E. A., Rossing, M., Rudaitis, V., Ruebner, M., Saloustros, E., Sanden, K., Santamarina, M., Scheuner, M. T., Schmutzler, R. K., Schneider, M., Scott, C., Senter, L., Shah, M., Sharma, P., Shu, X-O., Simard, J., Singer, C. F., Sohn, C., Soucy, P., Southey, M. C., Spinelli, J. J., Steele, L., Stoppa-Lyonnet, D., Tapper, W. J., Teixeira, M. R., Terry, M. B., Thomassen, M., Thompson, J., Thull, D. L., Tischkowitz, M., Tollenaar, R. A. E. M., Torres, D., Troester, M. A., Truong, T., Tung, N., Untch, M., Vachon, C. M., van Rensburg, E. J., van Veen, E. M., Vega, A., Viel, A., Wappenschmidt, B., Weitzel, J. N., Wendt, C., Wieme, G., Wolk, A., Yang, X. R., Zheng, W., Ziogas, A., Zorn, K. K., Dunning, A. M., Lush, M., Wang, Q., McGuffog, L., Parsons, M. T., Pharoah, P. D. P., Fostira, F., Toland, A. E., Andrulis, I. L., Ramus, S. J., Swerdlow, A. J., Greene, M. H., Chung, W. K., Milne, R. L., Chenevix-Trench, G., Dörk, T., Schmidt, M. K., Easton, D. F., Radice, P., Hahnen, E., Antoniou, A. C., Couch, F. J., Nevanlinna, H., Surralles, J. & Peterlongo, P., 1 Dec 2019, In : npj Breast Cancer. 5, 1, p. 1-14 14 p., 38.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
1 Downloads (Pure)

Whole genome sequencing of melanomas in adolescent and young adults reveals distinct mutation landscapes and the potential role of germline variants in disease susceptibility

Wilmott, J. S., Johansson, P. A., Newell, F., Waddell, N., Ferguson, P., Quek, C., Patch, A. M., Nones, K., Shang, P., Pritchard, A. L., Kazakoff, S., Holmes, O., Leonard, C., Wood, S., Xu, Q., Saw, R. P. M., Spillane, A. J., Stretch, J. R., Shannon, K. F., Kefford, R. F. & 7 others, Menzies, A. M., Long, G. V., Thompson, J. F., Pearson, J. V., Mann, G. J., Hayward, N. K. & Scolyer, R. A., 1 Mar 2019, In : International Journal of Cancer. 144, 5, p. 1049-1060 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Assessing the incremental contribution of common genomic variants to melanoma risk prediction in two population-based studies

Cust, A. E., Drummond, M., Kanetsky, P. A., Australian Melanoma Family Study Investigators, Leeds Case-Control Study Investigators, Goldstein, A. M., Barrett, J. H., MacGregor, S., Law, M. H., Iles, M. M., Bui, M., Hopper, J. L., Brossard, M., Demenais, F., Taylor, J. C., Hoggart, C., Brown, K. M., Landi, M. T., Newton-Bishop, J. A., Mann, G. J. & 1 others, Bishop, D. T., Dec 2018, In : Journal of Investigative Dermatology. 138, 12, p. 2617-2624 8 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
9 Downloads (Pure)

Association between circulating tumor DNA and pseudoprogression in patients with metastatic melanoma treated with anti–programmed cell death 1 antibodies

Lee, J. H., Long, G. V., Menzies, A. M., Lo, S., Guminski, A., Whitbourne, K., Peranec, M., Scolyer, R., Kefford, R. F., Rizos, H. & Carlino, M. S., 1 May 2018, In : JAMA Oncology. 4, 5, p. 717-721 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Baseline tumor size is an independent prognostic factor for overall survival in patients with melanoma treated with pembrolizumab

Joseph, R. W., Elassaiss-Schaap, J., Kefford, R., Hwu, W. J., Wolchok, J. D., Joshua, A. M., Ribas, A., Hodi, F. S., Hamid, O., Robert, C., Daud, A., Dronca, R., Hersey, P., Weber, J. S., Patnaik, A., de Alwis, D. P., Perrone, A., Zhang, J., Kang, S. P., Ebbinghaus, S. & 2 others, Anderson, K. M. & Gangadhar, T. C., 15 Oct 2018, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 24, 20, p. 4960-4967 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Durable complete response after discontinuation of pembrolizumab in patients with metastatic melanoma

Robert, C., Ribas, A., Hamid, O., Daud, A., Wolchok, J. D., Joshua, A. M., Hwu, W. J., Weber, J. S., Gangadhar, T. C., Joseph, R. W., Dronca, R., Patnaik, A., Zarour, H., Kefford, R., Hersey, P., Zhang, J., Anderson, J., Diede, S. J., Ebbinghaus, S. & Hodi, F. S., 10 Jun 2018, In : Journal of Clinical Oncology. 36, 17, p. 1668-1674 7 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Efficacy of novel immunotherapy regimens in patients with metastatic melanoma with germline CDKN2A mutations

Helgadottir, H., Ghiorzo, P., Van Doorn, R., Puig, S., Levin, M., Kefford, R., Lauss, M., Queirolo, P., Pastorino, L., Kapiteijn, E., Potrony, M., Carrera, C., Olsson, H., Höiom, V. & Jönsson, G., 5 Oct 2018, In : Journal of medical genetics.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Evaluation of commercial kits for purification of circulating free DNA

Diefenbach, R. J., Lee, J. H., Kefford, R. F. & Rizos, H., 21 Sep 2018, In : Cancer Genetics. 228-229, p. 21-27 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Heritable DNA methylation marks associated with susceptibility to breast cancer

Joo, J. E., Dowty, J. G., Milne, R. L., Wong, E. M., Dugué, P. A., kConFab, English, D., Hopper, J. L., Goldgar, D. E., Giles, G. G. & Southey, M. C., 1 Dec 2018, In : Nature Communications. 9, 1, p. 1-12 12 p., 867.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
12 Downloads (Pure)

History of Melanoma

Thompson, J. F., Kefford, R., Stevens, G. & Scolyer, R., 2018, Melanoma: a modern multidisciplinary approach. Riker, A. I. (ed.). Springer, Springer Nature, p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Interferon signaling is frequently downregulated in melanoma

Alavi, S., Stewart, A. J., Kefford, R. F., Lim, S. Y., Shklovskaya, E. & Rizos, H., 2018, In : Frontiers in Immunology. 9, p. 1-12 12 p., 1414.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
18 Downloads (Pure)

Liquid biomarkers in melanoma: detection and discovery

Lim, S. Y., Lee, J. H., Diefenbach, R. J., Kefford, R. F. & Rizos, H., 17 Jan 2018, In : Molecular Cancer. 17, 1, p. 1-14 14 p., 8.

Research output: Contribution to journalReview article

Open Access
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15 Citations (Scopus)
18 Downloads (Pure)

Longer follow-up confirms relapse-free survival benefit with adjuvant dabrafenib plus trametinib in patients with resected BRAF V600–mutant stage III melanoma

Hauschild, A., Dummer, R., Schadendorf, D., Santinami, M., Atkinson, V., Mandalà, M., Chiarion-Sileni, V., Larkin, J., Nyakas, M., Dutriaux, C., Haydon, A., Robert, C., Mortier, L., Schachter, J., Lesimple, T., Plummer, R., Dasgupta, K., Haas, T., Shilkrut, M., Gasal, E. & 3 others, Kefford, R., Kirkwood, J. M. & Long, G. V., 10 Dec 2018, In : Journal of Clinical Oncology. 36, 35, p. 3441-3449+ 13 p.

Research output: Contribution to journalArticle

Open Access
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52 Citations (Scopus)
19 Downloads (Pure)

Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma who received dabrafenib combined with trametinib

Long, G. V., Eroglu, Z., Infante, J., Patel, S., Daud, A., Johnson, D. B., Gonzalez, R., Kefford, R., Hamid, O., Schuchter, L., Cebon, J., Sharfman, W., McWilliams, R., Sznol, M., Redhu, S., Gasal, E., Mookerjee, B., Weber, J. & Flaherty, K. T., 1 Mar 2018, In : Journal of Clinical Oncology. 36, 7, p. 667-673 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Metastasis-specific patterns of response and progression with anti-PD-1 treatment in metastatic melanoma

Lee, J. H. J., Lyle, M., Menzies, A. M., Chan, M. M. K., Lo, S., Clements, A., Carlino, M. S., Kefford, R. F. & Long, G. V., 1 May 2018, In : Pigment Cell and Melanoma Research. 31, 3, p. 404-410 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Neoadjuvant systemic therapy for breast cancer: the Westmead experience

Cocco, A. M., Messer, D., Brown, A., Sriram, N., Gilchrist, J., Al-Mansouri, L., Kefford, R., Meybodi, F., French, J., Hsu, J. & Elder, E., 1 Jun 2018, In : ANZ Journal of Surgery. 88, 6, p. 640-644 5 p.

Research output: Contribution to journalArticle

Oncogenic PI3K/AKT promotes the step-wise evolution of combination BRAF/MEK inhibitor resistance in melanoma

Irvine, M., Stewart, A., Pedersen, B., Boyd, S., Kefford, R. & Rizos, H., 1 Sep 2018, In : Oncogenesis. 7, 9, p. 1-11 11 p., 72.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
14 Downloads (Pure)

Oncogenic signaling in uveal melanoma

Park, J., Diefenbach, R. J., Joshua, A. M., Kefford, R. F., Carlino, M. S. & Rizos, H., Nov 2018, In : Pigment Cell and Melanoma Research. 31, 6, p. 661-672 12 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
2017

Adjuvant dabrafenib plus trametinib in stage III BRAF-mutated melanoma

Long, G. V., Hauschild, A., Santinami, M., Atkinson, V., Mandal, M., Chiarion-Sileni, V., Larkin, J., Nyakas, M., Dutriaux, C., Haydon, A., Robert, C., Mortier, L., Schachter, J., Schadendorf, D., Lesimple, T., Plummer, R., Ji, R., Zhang, P., Mookerjee, B., Legos, J. & 3 others, Kefford, R., Dummer, R. & Kirkwood, J. M., 9 Nov 2017, In : New England Journal of Medicine. 377, 19, p. 1813-1823 11 p.

Research output: Contribution to journalArticle

389 Citations (Scopus)

Circulating tumour DNA predicts response to anti-PD1 antibodies in metastatic melanoma

Lee, J. H., Long, G. V., Boyd, S., Lo, S., Menzies, A. M., Tembe, V., Guminski, A., Jakrot, V., Scolyer, R. A., Mann, G. J., Kefford, R., Carlino, M. S. & Rizos, H., May 2017, In : Annals of Oncology. 28, 5, p. 1130-1136 7 p.

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88 Citations (Scopus)

Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing

Pupo, G. M., Boyd, S. C., Fung, C., Carlino, M. S., Menzies, A. M., Pedersen, B., Johansson, P., Hayward, N. K., Kefford, R. F., Scolyer, R. A., Long, G. V. & Rizos, H., 11 May 2017, In : Biomarker research. 5, 1, p. 1-4 4 p., 17.

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Dynamic changes in PD-L1 expression and immune infiltrates early during treatment predict response to PD-1 blockade in Melanoma

Vilain, R. E., Menzies, A. M., Wilmott, J. S., Kakavand, H., Madore, J., Guminski, A., Liniker, E., Kong, B. Y., Cooper, A. J., Howle, J. R., Saw, R. P. M., Jakrot, V., Lo, S., Thompson, J. F., Carlino, M. S., Kefford, R. F., Long, G. V. & Scolyer, R. A., 1 Sep 2017, In : Clinical Cancer Research. 23, 17, p. 5024-5033 10 p.

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59 Citations (Scopus)

Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases

Parakh, S., Park, J. J., Mendis, S., Rai, R., Xu, W., Lo, S., Drummond, M., Rowe, C., Wong, A., McArthur, G., Haydon, A., Andrews, M. C., Cebon, J., Guminski, A., Kefford, R. F., Long, G. V., Menzies, A. M., Klein, O. & Carlino, M. S., 6 Jun 2017, In : British Journal of Cancer. 116, 12, p. 1558-1563 6 p.

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40 Citations (Scopus)

Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients.

Lim, S. Y., Lee, J., Welsh, S. J., Ahn, S. B., Breen, E., Khan, A., Carlino, M. S., Menzies, A. M., Kefford, R. F., Scolyer, R. A., Long, G. V. & Rizos, H., 2017, In : Biomarker research. 5, p. 1-12 12 p., 32.

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Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Fang, J., Jia, J., Makowski, M., Xu, M., Wang, Z., Zhang, T., Hoskins, J. W., Choi, J., Han, Y., Zhang, M., Thomas, J., Kovacs, M., Collins, I., Dzyadyk, M., Thompson, A., O'Neill, M., Das, S., Lan, Q., Koster, R., PanScan Consortium & 24 others, TRICL Consortium, GenoMEL Consortium, Stolzenberg-Solomon, R. S., Kraft, P., Wolpin, B. M., Jansen, P. W. T. C., Olson, S. H., McGlynn, K. A., Kanetsky, P. A., Chatterjee, N., Barrett, J. H., Dunning, A. M., Taylor, J. C., Newton-Bishop, J. A., Timothy Bishop, D., Andresson, T., Petersen, G. M., Amos, C. I., Iles, M. M., Nathanson, K. L., Landi, M. T., Vermeulen, M., Brown, K. M. & Amundadottir, L. T., 27 Apr 2017, In : Nature Communications. 8, p. 1-15 15 p., 15034.

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Lethal aplastic anemia caused by dual immune checkpoint blockade in metastatic melanoma

Helgadottir, H., Kis, L., Ljungman, P., Larkin, J., Kefford, R., Ascierto, P. A., Hansson, J. & Masucci, G., 1 Jul 2017, In : Annals of oncology : official journal of the European Society for Medical Oncology. 28, 7, p. 1672-1673 2 p.

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PD-L1 expression and immune escape in melanoma resistance to MAPK inhibitors

Kakavand, H., Rawson, R. V., Pupo, G. M., Yang, J. Y. H., Menzies, A. M., Carlino, M. S., Kefford, R. F., Howle, J. R., Saw, R. P. M., Thompson, J. F., Wilmott, J. S., Long, G. V., Scolyer, R. A. & Rizos, H., 15 Oct 2017, In : Clinical Cancer Research. 23, 20, p. 6054-6061 8 p.

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Pharmacokinetics of dabrafenib in a patient with metastatic melanoma undergoing haemodialysis

Park, J. J., Boddy, A. V., Liu, X., Harris, D., Lee, V., Kefford, R. F. & Carlino, M. S., Jan 2017, In : Pigment Cell and Melanoma Research. 30, 1, p. 68-71 4 p.

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Phase I dose-escalation and -expansion study of the BRAF inhibitor encorafenib (LGX818) in metastatic BRAF-mutant melanoma

Delord, J. P., Robert, C., Nyakas, M., McArthur, G. A., Kudchakar, R., Mahipal, A., Yamada, Y., Sullivan, R., Arance, A., Kefford, R. F., Carlino, M. S., Hidalgo, M., Gomez-Roca, C., Michel, D., Seroutou, A., Aslanis, V., Caponigro, G., Stuart, D. D., Moutouh-De Parseval, L., Demuth, T. & 1 others, Dummer, R., 15 Sep 2017, In : Clinical Cancer Research. 23, 18, p. 5339-5348 10 p.

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Phase III randomized study of 4 weeks of high-dose interferon-α-2b in stage T2bNO, T3a-bNO, T4a-bNO, and T1-4N1a-2a (microscopic) melanoma: a trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E1697)

Agarwala, S. S., Lee, S. J., Yip, W., Rao, U. N., Tarhini, A. A., Cohen, G. I., Reintgen, D. S., Evans, T. L., Brell, J. M., Albertini, M. R., Atkins, M. B., Dakhil, S. R., Conry, R. M., Sosman, J. A., Flaherty, L. E., Sondak, V. K., Carson, W. E., Smylie, M. G., Pappo, A. S., Kefford, R. F. & 1 others, Kirkwood, J. M., 10 Mar 2017, In : Journal of Clinical Oncology. 35, 8, p. 885-892 11 p.

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21 Citations (Scopus)