Aβ amyloid, cognition, and APOE genotype in healthy older adults

Yen Ying Lim*, Kathryn A. Ellis, David Ames, David Darby, Karra Harrington, Ralph N. Martins, Colin L. Masters, Christopher Rowe, Greg Savage, Cassandra Szoeke, Victor L. Villemagne, Paul Maruff, The AIBL Research Group

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)

    Abstract

    Background: Only one study has investigated the relationship between cerebral β-amyloid (Aβ), apolipoprotein E (APOE) ε4 genotype, and cognition. Although significant relationships between cerebral Aβ and cognition were observed in ε4 carriers but not noncarriers, the magnitude of this relationship was not reported. Further, when demographic variables were controlled, the influence of APOE ε4 on the relationship between cerebral Aβ and cognition dissipated. Methods: In 144 healthy older adults who had undergone amyloid scanning and APOE ε4 genotyping in the Australian Imaging, Biomarkers, and Lifestyle (AIBL) Flagship Study of Ageing, correlations were conducted to determine the magnitude of relationship between cerebral Aβ and cognition in ε4 carriers and noncarriers. Fisher's Z was used to compare these correlations and Cohen's q determined the magnitude of difference between correlations. Results: Cerebral Aβ was significantly associated with tasks of visual and verbal episodic memory in APOE ε4 carriers. This association was not observed in ε4 noncarriers. The relationship between cerebral Aβ and episodic memory in ε4 carriers was significantly different from that in ε4 noncarriers, and the magnitude of this difference was small to moderate. Conclusions: In APOE ε4 carriers, there is a moderate negative relationship between cerebral Aβ and episodic memory. This suggests that increased cerebral Aβ may signify the onset of preclinical AD, especially in healthy older adults who are genetically at risk for AD.

    Original languageEnglish
    Pages (from-to)538-545
    Number of pages8
    JournalAlzheimer's and Dementia
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - Sep 2013

    Keywords

    • Cerebral Ab burden
    • APOE 34
    • episodic memory
    • healthy older adults
    • AIBL

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