A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors

Lin Ding, Mahsa Asadniaye Fardjahromi, Sajad Razavi Bazaz, Mohsen Asadnia, Graham Vesey, Majid Ebrahimi Warkiani*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Mesenchymal stem cell (MSC) therapy is a research hotspot nowadays due to its multiple therapeutic effects and novel application in diseases treatments. However, the current industrial technologies for their culture and harvesting are labour-intensive, time-consuming and very expensive. Herein, we presented a 3D printed modular microfluidic system consisting of micromixers and spiral channel units for cell harvesting which will greatly reduce the time and cost needed for cell harvesting, washing and cultivation. At the meantime, this system is automatic, making it compatible to the current Good Manufacturing Practice (cGMP).

Original languageEnglish
Title of host publicationMicroTAS 2019, the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages602-603
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name
ISSN (Electronic)1556-5904

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • 3D printing
  • Inertial microfluidics
  • Scale-up microfluidics
  • Micromixer
  • Industrial application

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