A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors

Lin Ding; Mahsa Asadniaye Fardjahromi; Sajad Razavi Bazaz; Mohsen Asadnia; Graham Vesey; Majid Ebrahimi Warkiani

A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors

Lin Ding, Mahsa Asadniaye Fardjahromi, Sajad Razavi Bazaz, Mohsen Asadnia, Graham Vesey, Majid Ebrahimi Warkiani^*

^*Corresponding author for this work

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

Abstract

Mesenchymal stem cell (MSC) therapy is a research hotspot nowadays due to its multiple therapeutic effects and novel application in diseases treatments. However, the current industrial technologies for their culture and harvesting are labour-intensive, time-consuming and very expensive. Herein, we presented a 3D printed modular microfluidic system consisting of micromixers and spiral channel units for cell harvesting which will greatly reduce the time and cost needed for cell harvesting, washing and cultivation. At the meantime, this system is automatic, making it compatible to the current Good Manufacturing Practice (cGMP).

Original language	English
Title of host publication	MicroTAS 2019, the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	602-603
Number of pages	2
ISBN (Electronic)	9781733419000
Publication status	Published - 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019

Publication series

Name
ISSN (Electronic)	1556-5904

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/Territory	Switzerland
City	Basel
Period	27/10/19 → 31/10/19

Keywords

3D printing
Inertial microfluidics
Scale-up microfluidics
Micromixer
Industrial application

Cite this

@inproceedings{58f6f85d93a04d979fa2f4a079e36b6d,

title = "A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors",

abstract = "Mesenchymal stem cell (MSC) therapy is a research hotspot nowadays due to its multiple therapeutic effects and novel application in diseases treatments. However, the current industrial technologies for their culture and harvesting are labour-intensive, time-consuming and very expensive. Herein, we presented a 3D printed modular microfluidic system consisting of micromixers and spiral channel units for cell harvesting which will greatly reduce the time and cost needed for cell harvesting, washing and cultivation. At the meantime, this system is automatic, making it compatible to the current Good Manufacturing Practice (cGMP).",

keywords = "3D printing, Inertial microfluidics, Scale-up microfluidics, Micromixer, Industrial application",

author = "Lin Ding and Fardjahromi, {Mahsa Asadniaye} and Bazaz, {Sajad Razavi} and Mohsen Asadnia and Graham Vesey and Warkiani, {Majid Ebrahimi}",

year = "2019",

language = "English",

publisher = "Chemical and Biological Microsystems Society",

pages = "602--603",

booktitle = "MicroTAS 2019, the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences",

note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

}

Ding, L, Fardjahromi, MA, Bazaz, SR, Asadnia, M, Vesey, G & Warkiani, ME 2019, A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors. in MicroTAS 2019, the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 602-603, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, Basel, Switzerland, 27/10/19.

A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors. / Ding, Lin; Fardjahromi, Mahsa Asadniaye; Bazaz, Sajad Razavi et al.

MicroTAS 2019, the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2019. p. 602-603.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

TY - GEN

T1 - A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors

AU - Ding, Lin

AU - Fardjahromi, Mahsa Asadniaye

AU - Bazaz, Sajad Razavi

AU - Asadnia, Mohsen

AU - Vesey, Graham

AU - Warkiani, Majid Ebrahimi

PY - 2019

Y1 - 2019

N2 - Mesenchymal stem cell (MSC) therapy is a research hotspot nowadays due to its multiple therapeutic effects and novel application in diseases treatments. However, the current industrial technologies for their culture and harvesting are labour-intensive, time-consuming and very expensive. Herein, we presented a 3D printed modular microfluidic system consisting of micromixers and spiral channel units for cell harvesting which will greatly reduce the time and cost needed for cell harvesting, washing and cultivation. At the meantime, this system is automatic, making it compatible to the current Good Manufacturing Practice (cGMP).

AB - Mesenchymal stem cell (MSC) therapy is a research hotspot nowadays due to its multiple therapeutic effects and novel application in diseases treatments. However, the current industrial technologies for their culture and harvesting are labour-intensive, time-consuming and very expensive. Herein, we presented a 3D printed modular microfluidic system consisting of micromixers and spiral channel units for cell harvesting which will greatly reduce the time and cost needed for cell harvesting, washing and cultivation. At the meantime, this system is automatic, making it compatible to the current Good Manufacturing Practice (cGMP).

KW - 3D printing

KW - Inertial microfluidics

KW - Scale-up microfluidics

KW - Micromixer

KW - Industrial application

UR - http://www.scopus.com/inward/record.url?scp=85094940162&partnerID=8YFLogxK

UR - https://cbmsociety.org/microtas/microtas_proceedings/

UR - http://purl.org/au-research/grants/arc/DP170103704

UR - http://purl.org/au-research/grants/arc/DP180103003

M3 - Conference proceeding contribution

AN - SCOPUS:85094940162

SP - 602

EP - 603

BT - MicroTAS 2019, the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Y2 - 27 October 2019 through 31 October 2019

ER -

A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors

Abstract

Publication series

Conference

Keywords

Other files and links

Fingerprint

Complete blood fractionation using a low-cost microfluidic system

Cite this

A 3D printed modular microfluidic device for large scale cell harvesting from bioreactors

Abstract

Publication series

Conference

Keywords

Other files and links

Fingerprint

Projects

Complete blood fractionation using a low-cost microfluidic system

Cite this