A brain-targeting NIR-II ferroptosis system: effective visualization and oncotherapy for orthotopic glioblastoma

Jing  Zhang; Lulu Han; Haigang  Wu; Yong Zhong; Ping Shangguan; Yisheng Liu; Mu He; Han Sun; Chenhui Song; Xin Wang; Yang Liu; Jiefeng Wang; Lei Zheng; Bingyang Shi; Ben Zhong Tang

doi:10.1002/advs.202206333

A brain-targeting NIR-II ferroptosis system: effective visualization and oncotherapy for orthotopic glioblastoma

Jing Zhang, Lulu Han, Haigang Wu, Yong Zhong, Ping Shangguan, Yisheng Liu, Mu He, Han Sun, Chenhui Song, Xin Wang, Yang Liu, Jiefeng Wang, Lei Zheng, Bingyang Shi^*, Ben Zhong Tang^*

^*Corresponding author for this work

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)-based NIR-II ferroptosis nanoparticles (TBTP-Au NPs) for brain-targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real-time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP-Au specifically activates the effective heme oxygenase-1-regulated ferroptosis of glioma cells to greatly extend the survival time of glioma-bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high-specificity visual anticancer drugs for clinical trials.

Original language	English
Article number	2206333
Number of pages	11
Journal	Advanced Science
Volume	10
Issue number	13
Early online date	3 Mar 2023
DOIs	https://doi.org/10.1002/advs.202206333
Publication status	Published - 5 May 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

aggregation-induced emission
brain-targeting
ferroptosis
glioma
near-infrared imaging

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10.1002/advs.202206333Licence: CC BY

Publisher version (open access)Final published version, 4.72 MBLicence: CC BY

Cite this

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title = "A brain-targeting NIR-II ferroptosis system: effective visualization and oncotherapy for orthotopic glioblastoma",

abstract = "Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)-based NIR-II ferroptosis nanoparticles (TBTP-Au NPs) for brain-targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real-time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP-Au specifically activates the effective heme oxygenase-1-regulated ferroptosis of glioma cells to greatly extend the survival time of glioma-bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high-specificity visual anticancer drugs for clinical trials.",

keywords = "aggregation-induced emission, brain-targeting, ferroptosis, glioma, near-infrared imaging",

author = "Jing Zhang and Lulu Han and Haigang Wu and Yong Zhong and Ping Shangguan and Yisheng Liu and Mu He and Han Sun and Chenhui Song and Xin Wang and Yang Liu and Jiefeng Wang and Lei Zheng and Bingyang Shi and Tang, {Ben Zhong}",

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T1 - A brain-targeting NIR-II ferroptosis system

T2 - effective visualization and oncotherapy for orthotopic glioblastoma

AU - Zhang, Jing

AU - Han, Lulu

AU - Wu, Haigang

AU - Zhong, Yong

AU - Shangguan, Ping

AU - Liu, Yisheng

AU - He, Mu

AU - Sun, Han

AU - Song, Chenhui

AU - Wang, Xin

AU - Liu, Yang

AU - Wang, Jiefeng

AU - Zheng, Lei

AU - Shi, Bingyang

AU - Tang, Ben Zhong

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/5/5

Y1 - 2023/5/5

N2 - Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)-based NIR-II ferroptosis nanoparticles (TBTP-Au NPs) for brain-targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real-time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP-Au specifically activates the effective heme oxygenase-1-regulated ferroptosis of glioma cells to greatly extend the survival time of glioma-bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high-specificity visual anticancer drugs for clinical trials.

AB - Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)-based NIR-II ferroptosis nanoparticles (TBTP-Au NPs) for brain-targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real-time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP-Au specifically activates the effective heme oxygenase-1-regulated ferroptosis of glioma cells to greatly extend the survival time of glioma-bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high-specificity visual anticancer drugs for clinical trials.

KW - aggregation-induced emission

KW - brain-targeting

KW - ferroptosis

KW - glioma

KW - near-infrared imaging

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A brain-targeting NIR-II ferroptosis system: effective visualization and oncotherapy for orthotopic glioblastoma

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