A bridge too far? Inference and extrapolation from model organisms in neuroscience

David Michael Kaplan*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Like many other biological sciences, research in modern experimental neuroscience is heavily reliant on a range of model organisms, including but not limited to rats, mice, monkeys, birds, fish, and insects. The model organism approach is extremely well established in contemporary neuroscience as a means to investigate the nature of mind and brain. According to one recent estimate, studies involving nonhuman animals account for more than half of all the research undertaken (Manger et al. 2008). Even more strikingly, approximately 40% of all studies focus on just two model organisms that are quite evolutionarily distant from humans – the rat and the mouse (primarily the species Rattus norvegicus and Mus musculus) (Manger et al. 2008; Keifer and Summers 2016). Given that two central goals of neuroscience are arguably to: understand the distinctive structure and function of the human brain; and develop therapies for human brain diseases such as Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis, among others, a fundamental question naturally arises concerning what can be learned indirectly about humans by studying the brains and nervous systems of nonhuman animals.
Original languageEnglish
Title of host publicationThe routledge handbook of philosophy of animal minds
EditorsKristin Andrews, Jacob Beck
Place of PublicationLondon
PublisherRoutledge, Taylor and Francis Group
Chapter43
Pages448-457
Number of pages10
ISBN (Electronic)9781315742250, 9781317585619
ISBN (Print)9781138822887
DOIs
Publication statusPublished - 2018

Publication series

NameRoutledge handbooks in philosophy

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    Kaplan, D. M. (2018). A bridge too far? Inference and extrapolation from model organisms in neuroscience. In K. Andrews, & J. Beck (Eds.), The routledge handbook of philosophy of animal minds (pp. 448-457). (Routledge handbooks in philosophy). London: Routledge, Taylor and Francis Group. https://doi.org/10.4324/9781315742250.ch43