A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins

Donald L. Jack; Michael L. Storms; Jason H. Tchieu; Ian T. Paulsen; Milton H. Saier

doi:10.1128/JB.182.8.2311-2313.2000

A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins

Donald L. Jack, Michael L. Storms, Jason H. Tchieu, Ian T. Paulsen, Milton H. Saier^*

^*Corresponding author for this work

Research output: Contribution to journal › Article

81 Citations (Scopus)

Abstract

The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.

Original language	English
Pages (from-to)	2311-2313
Number of pages	3
Journal	Journal of Bacteriology
Volume	182
Issue number	8
DOIs	https://doi.org/10.1128/JB.182.8.2311-2313.2000
Publication status	Published - Apr 2000
Externally published	Yes

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abstract = "The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.",

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AU - Saier, Milton H.

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AB - The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.

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DO - 10.1128/JB.182.8.2311-2313.2000

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