A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins

Donald L. Jack, Michael L. Storms, Jason H. Tchieu, Ian T. Paulsen, Milton H. Saier*

*Corresponding author for this work

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.

Original languageEnglish
Pages (from-to)2311-2313
Number of pages3
JournalJournal of Bacteriology
Volume182
Issue number8
DOIs
Publication statusPublished - Apr 2000
Externally publishedYes

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