Abstract
The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 2311-2313 |
| Number of pages | 3 |
| Journal | Journal of Bacteriology |
| Volume | 182 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 2000 |
| Externally published | Yes |
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Cite this
Jack, D. L., Storms, M. L., Tchieu, J. H., Paulsen, I. T., & Saier, M. H. (2000). A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins. Journal of Bacteriology, 182(8), 2311-2313. https://doi.org/10.1128/JB.182.8.2311-2313.2000