A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

Rae Anne Hardie; Erin Knight; Brigitte Bruneau; Christina Semeniuk; Kulvinder Gill; Nico Nagelkerke; Joshua Kimani; Charles Wachihi; Elizabeth Ngugi; Ma Luo; Francis A. Plummer

doi:10.1097/QAD.0b013e328311d1a0

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

Rae Anne Hardie, Erin Knight, Brigitte Bruneau, Christina Semeniuk, Kulvinder Gill, Nico Nagelkerke, Joshua Kimani, Charles Wachihi, Elizabeth Ngugi, Ma Luo^*, Francis A. Plummer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

Original language	English
Pages (from-to)	2038-2042
Number of pages	5
Journal	AIDS
Volume	22
Issue number	15
DOIs	https://doi.org/10.1097/QAD.0b013e328311d1a0
Publication status	Published - 2008
Externally published	Yes

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title = "A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers",

abstract = "A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.",

author = "Hardie, {Rae Anne} and Erin Knight and Brigitte Bruneau and Christina Semeniuk and Kulvinder Gill and Nico Nagelkerke and Joshua Kimani and Charles Wachihi and Elizabeth Ngugi and Ma Luo and Plummer, {Francis A.}",

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T1 - A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

AU - Hardie, Rae Anne

AU - Knight, Erin

AU - Bruneau, Brigitte

AU - Semeniuk, Christina

AU - Gill, Kulvinder

AU - Nagelkerke, Nico

AU - Kimani, Joshua

AU - Wachihi, Charles

AU - Ngugi, Elizabeth

AU - Luo, Ma

AU - Plummer, Francis A.

PY - 2008

Y1 - 2008

N2 - A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

AB - A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

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A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

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