A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

Rae Anne Hardie, Erin Knight, Brigitte Bruneau, Christina Semeniuk, Kulvinder Gill, Nico Nagelkerke, Joshua Kimani, Charles Wachihi, Elizabeth Ngugi, Ma Luo*, Francis A. Plummer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

Original languageEnglish
Pages (from-to)2038-2042
Number of pages5
JournalAIDS
Volume22
Issue number15
DOIs
Publication statusPublished - 2008
Externally publishedYes

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