A comparative study of the effect of submicron porous and smooth ultrafine-grained Ti-20Mo surfaces on osteoblast responses

Na Gui, Wei Xu*, Amanda N. Abraham, Damian E. Myers, Edwin L. H. Mayes, Kenong Xia, Ravi Shukla, Ma Qian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The surface of an orthopaedic implant plays a crucial role in determining the adsorption of proteins and cell functions. A detailed comparative study has been made of the in vitro osteoblast responses to coarse-grained (grain size: 500 μm), ultrafine-grained (grain size: 100 nm), coarse-porous (pore size: 350 nm), and fine-porous (pore size: 155 nm) surfaces of Ti-20Mo alloy. The purpose was to provide essential experimental data for future design of orthopaedic titanium implants for rapid osseointegration. Systematic original experimental data was produced for each type of surfaces in terms of surface wettability, cell morphology, adhesion, growth, and differentiation. Microscopic evidence was collected to reveal the detailed interplay between each characteristic surface with proteins or cells. Various new observations were discussed and compared with literature data. It was concluded that the coarse-porous surfaces offered the optimum topographical environment for osteoblasts and that the combination of ultrafine grains and considerable grain boundary areas is not an effective way to enhance cell growth and osteogenic capacity. Moreover, pore features (size and depth) have a greater effect than smooth surfaces on cell growth and osteogenic capacity. It proves that cells can discern the difference in pore size in the range of 100–350 nm.

Original languageEnglish
Pages (from-to)2020-2033
Number of pages14
JournalJournal of Biomedical Materials Research. Part A
Volume106A
Issue number7
DOIs
Publication statusPublished - Jul 2018

Keywords

  • Ti-20Mo
  • ultrafine grains
  • submicron porous surfaces
  • osteoblast responses
  • filopodia

Fingerprint

Dive into the research topics of 'A comparative study of the effect of submicron porous and smooth ultrafine-grained Ti-20Mo surfaces on osteoblast responses'. Together they form a unique fingerprint.

Cite this