A Comparison of nonlinear measures for the detection of cardiac autonomic neuropathy from heart rate variability

David Cornforth, Herbert F. Jelinek, Mika Tarvainen

Research output: Contribution to journalArticle

22 Citations (Scopus)
32 Downloads (Pure)


In this work we compare three multiscale measures for their ability to discriminate between participants having cardiac autonomic neuropathy (CAN) and aged controls. CAN is a disease that involves nerve damage leading to an abnormal control of heart rate, so one would expect disease progression to manifest in changes to heart rate variability (HRV). We applied multiscale entropy (MSE), multi fractal detrended fluctuation analysis (MFDFA), and Renyi entropy (RE) to recorded datasets of RR intervals. The latter measure provided the best separation (lowest p-value in Mann–Whitney tests) between classes of participants having CAN, early CAN or no CAN (controls). This comparison suggests the efficacy of RE as a measure for diagnosis of CAN and its progression, when compared to the other multiscale measures.
Original languageEnglish
Pages (from-to)1425-1440
Number of pages16
Issue number3
Publication statusPublished - 2015


Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • multiscale entropy
  • multi fractal detrended fluctuation analysis
  • Renyi entropy
  • heart rate variability
  • cardiac autonomic neuropathy
  • disease discrimination

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