A complement component C3-like protein from the tunicate, Styela plicata

D. A. Raftos*, S. V. Nair, J. Robbins, R. A. Newton, R. Peters

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)


    This study identifies a complement component C3-like protein in the solitary tunicate, Styela plicata. Three different polyclonal antibodies raised against C3 molecules from two species (humans and the tunicate, Halocynthia roretzi) were used to identify the C3-like protein in S. plicata hemolymph. The C3 cross-reactive protein is a 170 kDa heterodimer composed of polypeptides (116 and 80 kDa) that have molecular weights comparable to those of C3α and C3β from other species. Amino acid sequencing and amino acid composition analysis confirmed that the C3-like protein from S. plicata is closely related to C3 from H. roretzi.

    Original languageEnglish
    Pages (from-to)307-312
    Number of pages6
    JournalDevelopmental and Comparative Immunology
    Issue number4
    Publication statusPublished - 2002


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