A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly

Facundo Manes, Ricardo Jorge, Maria Morcuende, Toru Yamada, Sergio Paradiso, Robert G. Robinson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)

Abstract

Rapid transcranial magnetic stimulation (rTMS) applied to the left dorsal lateral frontal cortex has been shown to produce antidepressant effects. Older depressed patients, however, in one study showed a lower response rate than younger patients. The current study examined treatment response in 20 depressed, treatment-refractory patients (mean age 60.7 ± 9.8 years) given five sessions of rTMS at 20 Hz for 2 seconds over 20 trains at 80% of motor threshold or identical placebo stimulation, after patients had been withdrawn from their antidepressants. There were no significant differences in Hamilton Depression Scale scores either before or after treatment at 7 days' follow-up. There were three responders to active treatment and three to sham treatment and responders had significantly greater frontal lobe volume than nonresponders (p = .03). These findings suggest that the stimulation parameters used in this study were probably insufficient to produce treatment response and that frontal atrophy may interfere with the effectiveness of rTMS.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalInternational Psychogeriatrics
Volume13
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

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