Abstract
Optically pure enantiomers of pipecolic acid are conveniently prepared in high yield by reacting the racemate with Λ-β-[Co(R,R-picchxn)Cl2]+ (picchxn = N,N′-di(2-picolyl)1,2-diaminocyclohexane) and crystallization of pure internal diastereoisomers as perchlorate salts. Subsequent reactions give the free acid of either hand. The stereochemical course of the resolution is established unambiguously by a single-crystal X-ray analysis of one intermediate and a combination of CD and 1H NMR measurements.
Original language | English |
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Pages (from-to) | 1789-1794 |
Number of pages | 6 |
Journal | Journal of Coordination Chemistry |
Volume | 60 |
Issue number | 16 |
DOIs | |
Publication status | Published - Aug 2007 |