A coumarin-derived fluorescent chemosensor for selectively detecting Cu2+

Synthesis, DFT calculations and cell imaging applications

Fengjuan Chen*, Guozhen Liu, Yanjun Shi, Pinxian Xi, Ju Cheng, Jinpeng Hong, Rong Shen, Xiaojun Yao, Decheng Bai, Zhengzhi Zeng

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A novel coumarin-based fluorescent probe L ((4E)-4-((7-hydroxy-4-methyl-2- oxo-2H-chromen-8-yl) methyleneamino)-1,2-dihyydro-2,3-dimethyl-1-phenylpyrazol- 5-one) has been developed as a simple and efficient chemosensor which exhibits a significant fluorescence reduction in the presence of metal cations. This sensor exhibits high selectivity and sensitivity toward Cu2+ over other common cations. The mechanism for detecting copper was evaluated by time-dependent density functional theory (TD-DFT) calculations and the coordination mode was also confirmed by density functional theory (DFT) calculations. Furthermore, results of cell imaging in this study indicate that this new probe may be useful for detection and monitoring of Cu2+ in biological applications.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalTalanta
Volume124
DOIs
Publication statusPublished - 15 Jun 2014
Externally publishedYes

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