A couple with gastrointestinal stromal tumor (GIST)

Pirooz Poursoltan; Stephen Begbie

doi:10.1111/j.1743-7563.2009.01203.x

A couple with gastrointestinal stromal tumor (GIST)

Pirooz Poursoltan^*, Stephen Begbie

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

Abstract

We present a 70-year old woman with metastatic gastrointestinal stromal tumor (GIST) and her partner, a 79-year old man with multiple gastric GIST tumors. This tumor is considered a rare malignancy with a reported incidence of 6-13 new cases per million. Our patients were found to have different genetic mutations in the C-KIT gene as the cause of their disease but, given the rarity of this tumor, it raises a question about their possible exposure to carcinogens or another shared mechanism that might have been involved in the pathogenesis of this cancer.

Original language	English
Pages (from-to)	142-145
Number of pages	4
Journal	Asia-Pacific Journal of Clinical Oncology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1111/j.1743-7563.2009.01203.x
Publication status	Published - Jun 2009
Externally published	Yes

Keywords

TYROSINE KINASE
PHASE-I
IMATINIB
KIT
MUTATION

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10.1111/j.1743-7563.2009.01203.x

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title = "A couple with gastrointestinal stromal tumor (GIST)",

abstract = "We present a 70-year old woman with metastatic gastrointestinal stromal tumor (GIST) and her partner, a 79-year old man with multiple gastric GIST tumors. This tumor is considered a rare malignancy with a reported incidence of 6-13 new cases per million. Our patients were found to have different genetic mutations in the C-KIT gene as the cause of their disease but, given the rarity of this tumor, it raises a question about their possible exposure to carcinogens or another shared mechanism that might have been involved in the pathogenesis of this cancer.",

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AU - Begbie, Stephen

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N2 - We present a 70-year old woman with metastatic gastrointestinal stromal tumor (GIST) and her partner, a 79-year old man with multiple gastric GIST tumors. This tumor is considered a rare malignancy with a reported incidence of 6-13 new cases per million. Our patients were found to have different genetic mutations in the C-KIT gene as the cause of their disease but, given the rarity of this tumor, it raises a question about their possible exposure to carcinogens or another shared mechanism that might have been involved in the pathogenesis of this cancer.

AB - We present a 70-year old woman with metastatic gastrointestinal stromal tumor (GIST) and her partner, a 79-year old man with multiple gastric GIST tumors. This tumor is considered a rare malignancy with a reported incidence of 6-13 new cases per million. Our patients were found to have different genetic mutations in the C-KIT gene as the cause of their disease but, given the rarity of this tumor, it raises a question about their possible exposure to carcinogens or another shared mechanism that might have been involved in the pathogenesis of this cancer.

KW - TYROSINE KINASE

KW - PHASE-I

KW - IMATINIB

KW - KIT

KW - MUTATION

U2 - 10.1111/j.1743-7563.2009.01203.x

DO - 10.1111/j.1743-7563.2009.01203.x

M3 - Letter

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EP - 145

JO - Asia-Pacific Journal of Clinical Oncology

JF - Asia-Pacific Journal of Clinical Oncology

IS - 2

ER -

A couple with gastrointestinal stromal tumor (GIST)

Abstract

Keywords

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