TY - JOUR
T1 - A fresh look at the male-specific region of the human y chromosome
AU - Jangravi, Zohreh
AU - Alikhani, Mehdi
AU - Arefnezhad, Babak
AU - Tabar, Mehdi Sharifi
AU - Taleahmad, Sara
AU - Karamzadeh, Razieh
AU - Jadaliha, Mahdieh
AU - Mousavi, Seyed Ahmad
AU - Rastegar, Diba Ahmadi
AU - Parsamatin, Pouria
AU - Vakilian, Haghighat
AU - Mirshahvaladi, Shahab
AU - Sabbaghian, Marjan
AU - Meybodi, Anahita Mohseni
AU - Mirzaei, Mehdi
AU - Shahhoseini, Maryam
AU - Ebrahimi, Marzieh
AU - Piryaei, Abbas
AU - Moosavi-Movahedi, Ali Akbar
AU - Haynes, Paul A.
AU - Goodchild, Ann K.
AU - Nasr-Esfahani, Mohammad Hossein
AU - Jabbari, Esmaiel
AU - Baharvand, Hossein
AU - Sedighi Gilani, Mohammad Ali
AU - Gourabi, Hamid
AU - Salekdeh, Ghasem Hosseini
PY - 2013/1/4
Y1 - 2013/1/4
N2 - The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95% of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.
AB - The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95% of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.
UR - http://www.scopus.com/inward/record.url?scp=84874102705&partnerID=8YFLogxK
U2 - 10.1021/pr300864k
DO - 10.1021/pr300864k
M3 - Review article
C2 - 23253012
AN - SCOPUS:84874102705
VL - 12
SP - 6
EP - 22
JO - Journal of Proteome Research
JF - Journal of Proteome Research
SN - 1535-3893
IS - 1
ER -