A fresh look at the male-specific region of the human y chromosome

Zohreh Jangravi, Mehdi Alikhani, Babak Arefnezhad, Mehdi Sharifi Tabar, Sara Taleahmad, Razieh Karamzadeh, Mahdieh Jadaliha, Seyed Ahmad Mousavi, Diba Ahmadi Rastegar, Pouria Parsamatin, Haghighat Vakilian, Shahab Mirshahvaladi, Marjan Sabbaghian, Anahita Mohseni Meybodi, Mehdi Mirzaei, Maryam Shahhoseini, Marzieh Ebrahimi, Abbas Piryaei, Ali Akbar Moosavi-Movahedi, Paul A. Haynes & 7 others Ann K. Goodchild, Mohammad Hossein Nasr-Esfahani, Esmaiel Jabbari, Hossein Baharvand, Mohammad Ali Sedighi Gilani, Hamid Gourabi, Ghasem Hosseini Salekdeh

    Research output: Contribution to journalReview articleResearchpeer-review

    Abstract

    The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95% of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.

    LanguageEnglish
    Pages6-22
    Number of pages17
    JournalJournal of Proteome Research
    Volume12
    Issue number1
    DOIs
    Publication statusPublished - 4 Jan 2013

    Fingerprint

    Human Chromosomes
    Chromosomes
    Proteome
    Chromosomes, Human, Y
    Proteins
    RNA Sequence Analysis
    Genes
    Y Chromosome
    Haploidy
    Male Infertility
    Graft vs Host Disease
    Spermatogenesis
    Post Translational Protein Processing
    Iran
    Gene encoding
    Medical applications
    Fertility
    Biological systems
    Cell Biology
    Prostatic Neoplasms

    Cite this

    Jangravi, Z., Alikhani, M., Arefnezhad, B., Tabar, M. S., Taleahmad, S., Karamzadeh, R., ... Salekdeh, G. H. (2013). A fresh look at the male-specific region of the human y chromosome. Journal of Proteome Research, 12(1), 6-22. https://doi.org/10.1021/pr300864k
    Jangravi, Zohreh ; Alikhani, Mehdi ; Arefnezhad, Babak ; Tabar, Mehdi Sharifi ; Taleahmad, Sara ; Karamzadeh, Razieh ; Jadaliha, Mahdieh ; Mousavi, Seyed Ahmad ; Rastegar, Diba Ahmadi ; Parsamatin, Pouria ; Vakilian, Haghighat ; Mirshahvaladi, Shahab ; Sabbaghian, Marjan ; Meybodi, Anahita Mohseni ; Mirzaei, Mehdi ; Shahhoseini, Maryam ; Ebrahimi, Marzieh ; Piryaei, Abbas ; Moosavi-Movahedi, Ali Akbar ; Haynes, Paul A. ; Goodchild, Ann K. ; Nasr-Esfahani, Mohammad Hossein ; Jabbari, Esmaiel ; Baharvand, Hossein ; Sedighi Gilani, Mohammad Ali ; Gourabi, Hamid ; Salekdeh, Ghasem Hosseini. / A fresh look at the male-specific region of the human y chromosome. In: Journal of Proteome Research. 2013 ; Vol. 12, No. 1. pp. 6-22.
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    abstract = "The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95{\%} of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.",
    author = "Zohreh Jangravi and Mehdi Alikhani and Babak Arefnezhad and Tabar, {Mehdi Sharifi} and Sara Taleahmad and Razieh Karamzadeh and Mahdieh Jadaliha and Mousavi, {Seyed Ahmad} and Rastegar, {Diba Ahmadi} and Pouria Parsamatin and Haghighat Vakilian and Shahab Mirshahvaladi and Marjan Sabbaghian and Meybodi, {Anahita Mohseni} and Mehdi Mirzaei and Maryam Shahhoseini and Marzieh Ebrahimi and Abbas Piryaei and Moosavi-Movahedi, {Ali Akbar} and Haynes, {Paul A.} and Goodchild, {Ann K.} and Nasr-Esfahani, {Mohammad Hossein} and Esmaiel Jabbari and Hossein Baharvand and {Sedighi Gilani}, {Mohammad Ali} and Hamid Gourabi and Salekdeh, {Ghasem Hosseini}",
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    Jangravi, Z, Alikhani, M, Arefnezhad, B, Tabar, MS, Taleahmad, S, Karamzadeh, R, Jadaliha, M, Mousavi, SA, Rastegar, DA, Parsamatin, P, Vakilian, H, Mirshahvaladi, S, Sabbaghian, M, Meybodi, AM, Mirzaei, M, Shahhoseini, M, Ebrahimi, M, Piryaei, A, Moosavi-Movahedi, AA, Haynes, PA, Goodchild, AK, Nasr-Esfahani, MH, Jabbari, E, Baharvand, H, Sedighi Gilani, MA, Gourabi, H & Salekdeh, GH 2013, 'A fresh look at the male-specific region of the human y chromosome', Journal of Proteome Research, vol. 12, no. 1, pp. 6-22. https://doi.org/10.1021/pr300864k

    A fresh look at the male-specific region of the human y chromosome. / Jangravi, Zohreh; Alikhani, Mehdi; Arefnezhad, Babak; Tabar, Mehdi Sharifi; Taleahmad, Sara; Karamzadeh, Razieh; Jadaliha, Mahdieh; Mousavi, Seyed Ahmad; Rastegar, Diba Ahmadi; Parsamatin, Pouria; Vakilian, Haghighat; Mirshahvaladi, Shahab; Sabbaghian, Marjan; Meybodi, Anahita Mohseni; Mirzaei, Mehdi; Shahhoseini, Maryam; Ebrahimi, Marzieh; Piryaei, Abbas; Moosavi-Movahedi, Ali Akbar; Haynes, Paul A.; Goodchild, Ann K.; Nasr-Esfahani, Mohammad Hossein; Jabbari, Esmaiel; Baharvand, Hossein; Sedighi Gilani, Mohammad Ali; Gourabi, Hamid; Salekdeh, Ghasem Hosseini.

    In: Journal of Proteome Research, Vol. 12, No. 1, 04.01.2013, p. 6-22.

    Research output: Contribution to journalReview articleResearchpeer-review

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    T1 - A fresh look at the male-specific region of the human y chromosome

    AU - Jangravi, Zohreh

    AU - Alikhani, Mehdi

    AU - Arefnezhad, Babak

    AU - Tabar, Mehdi Sharifi

    AU - Taleahmad, Sara

    AU - Karamzadeh, Razieh

    AU - Jadaliha, Mahdieh

    AU - Mousavi, Seyed Ahmad

    AU - Rastegar, Diba Ahmadi

    AU - Parsamatin, Pouria

    AU - Vakilian, Haghighat

    AU - Mirshahvaladi, Shahab

    AU - Sabbaghian, Marjan

    AU - Meybodi, Anahita Mohseni

    AU - Mirzaei, Mehdi

    AU - Shahhoseini, Maryam

    AU - Ebrahimi, Marzieh

    AU - Piryaei, Abbas

    AU - Moosavi-Movahedi, Ali Akbar

    AU - Haynes, Paul A.

    AU - Goodchild, Ann K.

    AU - Nasr-Esfahani, Mohammad Hossein

    AU - Jabbari, Esmaiel

    AU - Baharvand, Hossein

    AU - Sedighi Gilani, Mohammad Ali

    AU - Gourabi, Hamid

    AU - Salekdeh, Ghasem Hosseini

    PY - 2013/1/4

    Y1 - 2013/1/4

    N2 - The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95% of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.

    AB - The Chromosome-centric Human Proteome Project (C-HPP) aims to systematically map the entire human proteome with the intent to enhance our understanding of human biology at the cellular level. This project attempts simultaneously to establish a sound basis for the development of diagnostic, prognostic, therapeutic, and preventive medical applications. In Iran, current efforts focus on mapping the proteome of the human Y chromosome. The male-specific region of the Y chromosome (MSY) is unique in many aspects and comprises 95% of the chromosome's length. The MSY continually retains its haploid state and is full of repeated sequences. It is responsible for important biological roles such as sex determination and male fertility. Here, we present the most recent update of MSY protein-encoding genes and their association with various traits and diseases including sex determination and reversal, spermatogenesis and male infertility, cancers such as prostate cancers, sex-specific effects on the brain and behavior, and graft-versus-host disease. We also present information available from RNA sequencing, protein-protein interaction, post-translational modification of MSY protein-coding genes and their implications in biological systems. An overview of Human Y chromosome Proteome Project is presented and a systematic approach is suggested to ensure that at least one of each predicted protein-coding gene's major representative proteins will be characterized in the context of its major anatomical sites of expression, its abundance, and its functional relevance in a biological and/or medical context. There are many technical and biological issues that will need to be overcome in order to accomplish the full scale mapping.

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    Jangravi Z, Alikhani M, Arefnezhad B, Tabar MS, Taleahmad S, Karamzadeh R et al. A fresh look at the male-specific region of the human y chromosome. Journal of Proteome Research. 2013 Jan 4;12(1):6-22. https://doi.org/10.1021/pr300864k