A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai*, Zhaoming Wang, Sonja I. Berndt, Christine F. Skibola, Susan L. Slager, Silvia De Sanjose, Mads Melbye, Bengt Glimelius, Paige M. Bracci, Lucia Conde, Brenda M. Birmann, Sophia S. Wang, Angela R. Brooks-Wilson, Qing Lan, Paul I. W. De Bakker, Roel C. H. Vermeulen, Carol Portlock, Stephen M. Ansell, Brian K. Link, Jacques RibyKari E. North, Jian Gu, Henrik Hjalgrim, Wendy Cozen, Nikolaus Becker, Lauren R. Teras, John J. Spinelli, Jenny Turner, Yawei Zhang, Mark P. Purdue, Graham G. Giles, Rachel S. Kelly, Anne Zeleniuch-Jacquotte, Maria Grazia Ennas, Alain Monnereau, Kimberly A. Bertrand, Demetrius Albanes, Tracy Lightfoot, Meredith Yeager, Charles C. Chung, Laurie Burdett, Amy Hutchinson, Charles Lawrence, Rebecca Montalvan, Liming Liang, Jinyan Huang, Baoshan Ma, Danylo J. Villano, Ann Maria, Marina Corines, Tinu Thomas, Anne J. Novak, Ahmet Dogan, Mark Liebow, Carrie A. Thompson, Thomas E. Witzig, Thomas M. Habermann, George J. Weiner, Martyn T. Smith, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yuanqing Ye, Hans Olov Adami, Karin E. Smedby, Anneclaire J. De Roos, Patricia Hartge, Lindsay M. Morton, Richard K. Severson, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, W. Ryan DIver, Claire M. Vajdic, Bruce K. Armstrong, Anne Kricker, Tongzhang Zheng, Theodore R. Holford, Gianluca Severi, Paolo Vineis, Giovanni M. Ferri, Rosalia Ricco, Lucia Miligi, Jacqueline Clavel, Edward Giovannucci, Peter Kraft, Jarmo Virtamo, Alex Smith, Eleanor Kane, Eve Roman, Brian C. H. Chiu, Joseph F. Fraumeni, Xifeng Wu, James R. Cerhan, Kenneth Offit, Stephen J. Chanock, Nathaniel Rothman, Alexandra Nieters

*Corresponding author for this work

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    Abstract

    Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10-15) and HLA-B (rs2922994, P=2.43 × 10-9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

    Original languageEnglish
    Article number5751
    Pages (from-to)1-7
    Number of pages7
    JournalNature Communications
    Volume6
    DOIs
    Publication statusPublished - 8 Jan 2015

    Bibliographical note

    Copyright Macmillan Publishers 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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