A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai; Zhaoming Wang; Sonja I. Berndt; Christine F. Skibola; Susan L. Slager; Silvia De Sanjose; Mads Melbye; Bengt Glimelius; Paige M. Bracci; Lucia Conde; Brenda M. Birmann; Sophia S. Wang; Angela R. Brooks-Wilson; Qing Lan; Paul I. W. De Bakker; Roel C. H. Vermeulen; Carol Portlock; Stephen M. Ansell; Brian K. Link; Jacques Riby; Kari E. North; Jian Gu; Henrik Hjalgrim; Wendy Cozen; Nikolaus Becker; Lauren R. Teras; John J. Spinelli; Jenny Turner; Yawei Zhang; Mark P. Purdue; Graham G. Giles; Rachel S. Kelly; Anne Zeleniuch-Jacquotte; Maria Grazia Ennas; Alain Monnereau; Kimberly A. Bertrand; Demetrius Albanes; Tracy Lightfoot; Meredith Yeager; Charles C. Chung; Laurie Burdett; Amy Hutchinson; Charles Lawrence; Rebecca Montalvan; Liming Liang; Jinyan Huang; Baoshan Ma; Danylo J. Villano; Ann Maria; Marina Corines; Tinu Thomas; Anne J. Novak; Ahmet Dogan; Mark Liebow; Carrie A. Thompson; Thomas E. Witzig; Thomas M. Habermann; George J. Weiner; Martyn T. Smith; Elizabeth A. Holly; Rebecca D. Jackson; Lesley F. Tinker; Yuanqing Ye; Hans Olov Adami; Karin E. Smedby; Anneclaire J. De Roos; Patricia Hartge; Lindsay M. Morton; Richard K. Severson; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; W. Ryan DIver; Claire M. Vajdic; Bruce K. Armstrong; Anne Kricker; Tongzhang Zheng; Theodore R. Holford; Gianluca Severi; Paolo Vineis; Giovanni M. Ferri; Rosalia Ricco; Lucia Miligi; Jacqueline Clavel; Edward Giovannucci; Peter Kraft; Jarmo Virtamo; Alex Smith; Eleanor Kane; Eve Roman; Brian C. H. Chiu; Joseph F. Fraumeni; Xifeng Wu; James R. Cerhan; Kenneth Offit; Stephen J. Chanock; Nathaniel Rothman; Alexandra Nieters

doi:10.1038/ncomms6751

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai^*, Zhaoming Wang, Sonja I. Berndt, Christine F. Skibola, Susan L. Slager, Silvia De Sanjose, Mads Melbye, Bengt Glimelius, Paige M. Bracci, Lucia Conde, Brenda M. Birmann, Sophia S. Wang, Angela R. Brooks-Wilson, Qing Lan, Paul I. W. De Bakker, Roel C. H. Vermeulen, Carol Portlock, Stephen M. Ansell, Brian K. Link, Jacques RibyKari E. North, Jian Gu, Henrik Hjalgrim, Wendy Cozen, Nikolaus Becker, Lauren R. Teras, John J. Spinelli, Jenny Turner, Yawei Zhang, Mark P. Purdue, Graham G. Giles, Rachel S. Kelly, Anne Zeleniuch-Jacquotte, Maria Grazia Ennas, Alain Monnereau, Kimberly A. Bertrand, Demetrius Albanes, Tracy Lightfoot, Meredith Yeager, Charles C. Chung, Laurie Burdett, Amy Hutchinson, Charles Lawrence, Rebecca Montalvan, Liming Liang, Jinyan Huang, Baoshan Ma, Danylo J. Villano, Ann Maria, Marina Corines, Tinu Thomas, Anne J. Novak, Ahmet Dogan, Mark Liebow, Carrie A. Thompson, Thomas E. Witzig, Thomas M. Habermann, George J. Weiner, Martyn T. Smith, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yuanqing Ye, Hans Olov Adami, Karin E. Smedby, Anneclaire J. De Roos, Patricia Hartge, Lindsay M. Morton, Richard K. Severson, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, W. Ryan DIver, Claire M. Vajdic, Bruce K. Armstrong, Anne Kricker, Tongzhang Zheng, Theodore R. Holford, Gianluca Severi, Paolo Vineis, Giovanni M. Ferri, Rosalia Ricco, Lucia Miligi, Jacqueline Clavel, Edward Giovannucci, Peter Kraft, Jarmo Virtamo, Alex Smith, Eleanor Kane, Eve Roman, Brian C. H. Chiu, Joseph F. Fraumeni, Xifeng Wu, James R. Cerhan, Kenneth Offit, Stephen J. Chanock, Nathaniel Rothman, Alexandra Nieters

^*Corresponding author for this work

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Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10^-15) and HLA-B (rs2922994, P=2.43 × 10^-9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Original language	English
Article number	5751
Pages (from-to)	1-7
Number of pages	7
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms6751
Publication status	Published - 8 Jan 2015

Bibliographical note

Copyright Macmillan Publishers 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Vijai, J., Wang, Z., Berndt, S. I., Skibola, C. F., Slager, S. L., De Sanjose, S., Melbye, M., Glimelius, B., Bracci, P. M., Conde, L., Birmann, B. M., Wang, S. S., Brooks-Wilson, A. R., Lan, Q., De Bakker, P. I. W., Vermeulen, R. C. H., Portlock, C., Ansell, S. M., Link, B. K., ... Nieters, A. (2015). A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature Communications, 6, 1-7. Article 5751. https://doi.org/10.1038/ncomms6751

@article{ee8d3abbc4c74a0fb1fa6a145e2fcb4d,

title = "A genome-wide association study of marginal zone lymphoma shows association to the HLA region",

abstract = "Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10-15) and HLA-B (rs2922994, P=2.43 × 10-9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.",

author = "Joseph Vijai and Zhaoming Wang and Berndt, \{Sonja I.\} and Skibola, \{Christine F.\} and Slager, \{Susan L.\} and \{De Sanjose\}, Silvia and Mads Melbye and Bengt Glimelius and Bracci, \{Paige M.\} and Lucia Conde and Birmann, \{Brenda M.\} and Wang, \{Sophia S.\} and Brooks-Wilson, \{Angela R.\} and Qing Lan and \{De Bakker\}, \{Paul I. W.\} and Vermeulen, \{Roel C. H.\} and Carol Portlock and Ansell, \{Stephen M.\} and Link, \{Brian K.\} and Jacques Riby and North, \{Kari E.\} and Jian Gu and Henrik Hjalgrim and Wendy Cozen and Nikolaus Becker and Teras, \{Lauren R.\} and Spinelli, \{John J.\} and Jenny Turner and Yawei Zhang and Purdue, \{Mark P.\} and Giles, \{Graham G.\} and Kelly, \{Rachel S.\} and Anne Zeleniuch-Jacquotte and Ennas, \{Maria Grazia\} and Alain Monnereau and Bertrand, \{Kimberly A.\} and Demetrius Albanes and Tracy Lightfoot and Meredith Yeager and Chung, \{Charles C.\} and Laurie Burdett and Amy Hutchinson and Charles Lawrence and Rebecca Montalvan and Liming Liang and Jinyan Huang and Baoshan Ma and Villano, \{Danylo J.\} and Ann Maria and Marina Corines and Tinu Thomas and Novak, \{Anne J.\} and Ahmet Dogan and Mark Liebow and Thompson, \{Carrie A.\} and Witzig, \{Thomas E.\} and Habermann, \{Thomas M.\} and Weiner, \{George J.\} and Smith, \{Martyn T.\} and Holly, \{Elizabeth A.\} and Jackson, \{Rebecca D.\} and Tinker, \{Lesley F.\} and Yuanqing Ye and Adami, \{Hans Olov\} and Smedby, \{Karin E.\} and \{De Roos\}, \{Anneclaire J.\} and Patricia Hartge and Morton, \{Lindsay M.\} and Severson, \{Richard K.\} and Yolanda Benavente and Paolo Boffetta and Paul Brennan and Lenka Foretova and Marc Maynadie and James McKay and Anthony Staines and DIver, \{W. Ryan\} and Vajdic, \{Claire M.\} and Armstrong, \{Bruce K.\} and Anne Kricker and Tongzhang Zheng and Holford, \{Theodore R.\} and Gianluca Severi and Paolo Vineis and Ferri, \{Giovanni M.\} and Rosalia Ricco and Lucia Miligi and Jacqueline Clavel and Edward Giovannucci and Peter Kraft and Jarmo Virtamo and Alex Smith and Eleanor Kane and Eve Roman and Chiu, \{Brian C. H.\} and Fraumeni, \{Joseph F.\} and Xifeng Wu and Cerhan, \{James R.\} and Kenneth Offit and Chanock, \{Stephen J.\} and Nathaniel Rothman and Alexandra Nieters",

note = "Copyright Macmillan Publishers 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2015",

month = jan,

day = "8",

doi = "10.1038/ncomms6751",

language = "English",

volume = "6",

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journal = "Nature Communications",

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Vijai, J, Wang, Z, Berndt, SI, Skibola, CF, Slager, SL, De Sanjose, S, Melbye, M, Glimelius, B, Bracci, PM, Conde, L, Birmann, BM, Wang, SS, Brooks-Wilson, AR, Lan, Q, De Bakker, PIW, Vermeulen, RCH, Portlock, C, Ansell, SM, Link, BK, Riby, J, North, KE, Gu, J, Hjalgrim, H, Cozen, W, Becker, N, Teras, LR, Spinelli, JJ, Turner, J, Zhang, Y, Purdue, MP, Giles, GG, Kelly, RS, Zeleniuch-Jacquotte, A, Ennas, MG, Monnereau, A, Bertrand, KA, Albanes, D, Lightfoot, T, Yeager, M, Chung, CC, Burdett, L, Hutchinson, A, Lawrence, C, Montalvan, R, Liang, L, Huang, J, Ma, B, Villano, DJ, Maria, A, Corines, M, Thomas, T, Novak, AJ, Dogan, A, Liebow, M, Thompson, CA, Witzig, TE, Habermann, TM, Weiner, GJ, Smith, MT, Holly, EA, Jackson, RD, Tinker, LF, Ye, Y, Adami, HO, Smedby, KE, De Roos, AJ, Hartge, P, Morton, LM, Severson, RK, Benavente, Y, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, DIver, WR, Vajdic, CM, Armstrong, BK, Kricker, A, Zheng, T, Holford, TR, Severi, G, Vineis, P, Ferri, GM, Ricco, R, Miligi, L, Clavel, J, Giovannucci, E, Kraft, P, Virtamo, J, Smith, A, Kane, E, Roman, E, Chiu, BCH, Fraumeni, JF, Wu, X, Cerhan, JR, Offit, K, Chanock, SJ, Rothman, N & Nieters, A 2015, 'A genome-wide association study of marginal zone lymphoma shows association to the HLA region', Nature Communications, vol. 6, 5751, pp. 1-7. https://doi.org/10.1038/ncomms6751

TY - JOUR

T1 - A genome-wide association study of marginal zone lymphoma shows association to the HLA region

AU - Vijai, Joseph

AU - Wang, Zhaoming

AU - Berndt, Sonja I.

AU - Skibola, Christine F.

AU - Slager, Susan L.

AU - De Sanjose, Silvia

AU - Melbye, Mads

AU - Glimelius, Bengt

AU - Bracci, Paige M.

AU - Conde, Lucia

AU - Birmann, Brenda M.

AU - Wang, Sophia S.

AU - Brooks-Wilson, Angela R.

AU - Lan, Qing

AU - De Bakker, Paul I. W.

AU - Vermeulen, Roel C. H.

AU - Portlock, Carol

AU - Ansell, Stephen M.

AU - Link, Brian K.

AU - Riby, Jacques

AU - North, Kari E.

AU - Gu, Jian

AU - Hjalgrim, Henrik

AU - Cozen, Wendy

AU - Becker, Nikolaus

AU - Teras, Lauren R.

AU - Spinelli, John J.

AU - Turner, Jenny

AU - Zhang, Yawei

AU - Purdue, Mark P.

AU - Giles, Graham G.

AU - Kelly, Rachel S.

AU - Zeleniuch-Jacquotte, Anne

AU - Ennas, Maria Grazia

AU - Monnereau, Alain

AU - Bertrand, Kimberly A.

AU - Albanes, Demetrius

AU - Lightfoot, Tracy

AU - Yeager, Meredith

AU - Chung, Charles C.

AU - Burdett, Laurie

AU - Hutchinson, Amy

AU - Lawrence, Charles

AU - Montalvan, Rebecca

AU - Liang, Liming

AU - Huang, Jinyan

AU - Ma, Baoshan

AU - Villano, Danylo J.

AU - Maria, Ann

AU - Corines, Marina

AU - Thomas, Tinu

AU - Novak, Anne J.

AU - Dogan, Ahmet

AU - Liebow, Mark

AU - Thompson, Carrie A.

AU - Witzig, Thomas E.

AU - Habermann, Thomas M.

AU - Weiner, George J.

AU - Smith, Martyn T.

AU - Holly, Elizabeth A.

AU - Jackson, Rebecca D.

AU - Tinker, Lesley F.

AU - Ye, Yuanqing

AU - Adami, Hans Olov

AU - Smedby, Karin E.

AU - De Roos, Anneclaire J.

AU - Hartge, Patricia

AU - Morton, Lindsay M.

AU - Severson, Richard K.

AU - Benavente, Yolanda

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Foretova, Lenka

AU - Maynadie, Marc

AU - McKay, James

AU - Staines, Anthony

AU - DIver, W. Ryan

AU - Vajdic, Claire M.

AU - Armstrong, Bruce K.

AU - Kricker, Anne

AU - Zheng, Tongzhang

AU - Holford, Theodore R.

AU - Severi, Gianluca

AU - Vineis, Paolo

AU - Ferri, Giovanni M.

AU - Ricco, Rosalia

AU - Miligi, Lucia

AU - Clavel, Jacqueline

AU - Giovannucci, Edward

AU - Kraft, Peter

AU - Virtamo, Jarmo

AU - Smith, Alex

AU - Kane, Eleanor

AU - Roman, Eve

AU - Chiu, Brian C. H.

AU - Fraumeni, Joseph F.

AU - Wu, Xifeng

AU - Cerhan, James R.

AU - Offit, Kenneth

AU - Chanock, Stephen J.

AU - Rothman, Nathaniel

AU - Nieters, Alexandra

N1 - Copyright Macmillan Publishers 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/1/8

Y1 - 2015/1/8

N2 - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10-15) and HLA-B (rs2922994, P=2.43 × 10-9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

AB - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10-15) and HLA-B (rs2922994, P=2.43 × 10-9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

UR - https://www.scopus.com/pages/publications/84929662642

U2 - 10.1038/ncomms6751

DO - 10.1038/ncomms6751

M3 - Article

C2 - 25569183

AN - SCOPUS:84929662642

SN - 2041-1723

VL - 6

SP - 1

EP - 7

JO - Nature Communications

JF - Nature Communications

M1 - 5751

ER -

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

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