A high-resolution single photon emission computed tomography study of verbal recognition memory in Alzheimer's disease

Julian N. Trollor*, Perminder S. Sachdev, Walter Haindl, Henry Brodaty, Wei Wen, Brenda M. Walker

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: In view of the recent technological advances and its ease of availability, we used single photon emission computed tomography (SPECT) to examine the performance of early Alzheimer's disease (AD) subjects on a verbal recognition memory task. Methods: Eighteen early AD and 10 matched healthy control subjects underwent split-dose 99mTc-HMPAO (Ceretec®) SPECT using a verbal recognition memory and control task. SPECT images co-registered with MRI scans were used to determine relative regional cerebral blood flow (rCBF) changes in regions of interest. Results: In healthy control subjects, verbal recognition increased rCBF in the right occipital region, thalamus, left prefrontal pole, posterior parietal region and cerebellum, and decreased rCBF in the right hippocampus. AD subjects showed bilateral prefrontal, posterior parietal and occipital increases, unilateral increase in the left posterior temporal region, and bilateral reductions in the hippocampus. Although activation was significantly different between the two groups in the right thalamus and left medial prefrontal region, the verbal recognition task did not enhance discrimination between groups. Conclusions: Compared with controls, AD subjects activate a similar but more extensive bilateral network during verbal recognition, possibly reflecting an attempt to compensate for impaired processing.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Magnetic resonance imaging coregistration
  • Regional cerebral blood flow
  • Single photon emission computed tomography
  • Verbal recognition

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