TY - JOUR
T1 - A high-stringency blueprint of the human proteome
AU - Adhikari, Subash
AU - Nice, Edouard C.
AU - Deutsch, Eric W.
AU - Lane, Lydie
AU - Omenn, Gilbert S.
AU - Pennington, Stephen R.
AU - Paik, Young-Ki
AU - Overall, Christopher M.
AU - Corrales, Fernando J.
AU - Cristea, Ileana M.
AU - Van Eyk, Jennifer E.
AU - Uhlen, Mathias
AU - Lindskog, Cecilia
AU - Chan, Daniel W.
AU - Bairoch, Amos
AU - Waddington, James C.
AU - Justice, Joshua L.
AU - LaBaer, Joshua
AU - Rodriguez, Henry
AU - He, Fuchu
AU - Kostrzewa, Markus
AU - Ping, Peipei
AU - Gundry, Rebekah L.
AU - Stewart, Peter
AU - Srivastava, Sanjeeva
AU - Srivastava, Sudhir
AU - Nogueira, Fabio C. S.
AU - Domont, Gilberto B.
AU - Vandenbrouck, Yves
AU - Lam, Maggie P. Y.
AU - Wennersten, Sara
AU - Vizcaino, Juan Antonio
AU - Wilkins, Marc
AU - Schwenk, Jochen M.
AU - Lundberg, Emma
AU - Bandeira, Nuno
AU - Marko-Varga, Gyorgy
AU - Weintraub, Susan T.
AU - Pineau, Charles
AU - Kusebauch, Ulrike
AU - Moritz, Robert L.
AU - Ahn, Seong Beom
AU - Palmblad, Magnus
AU - Snyder, Michael P.
AU - Aebersold, Ruedi
AU - Baker, Mark S.
N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2020/10/16
Y1 - 2020/10/16
N2 - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases. The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency and discussing the implications of proteomics for precision medicine.
AB - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases. The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency and discussing the implications of proteomics for precision medicine.
UR - http://purl.org/au-research/grants/nhmrc/1010303
UR - http://www.scopus.com/inward/record.url?scp=85092744472&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-19045-9
DO - 10.1038/s41467-020-19045-9
M3 - Article
C2 - 33067450
VL - 11
SP - 1
EP - 16
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 5301
ER -