A high-stringency blueprint of the human proteome

Subash Adhikari; Edouard C. Nice; Eric W. Deutsch; Lydie Lane; Gilbert S. Omenn; Stephen R. Pennington; Young-Ki Paik; Christopher M. Overall; Fernando J. Corrales; Ileana M. Cristea; Jennifer E. Van Eyk; Mathias Uhlen; Cecilia Lindskog; Daniel W. Chan; Amos Bairoch; James C. Waddington; Joshua L. Justice; Joshua LaBaer; Henry Rodriguez; Fuchu He; Markus Kostrzewa; Peipei Ping; Rebekah L. Gundry; Peter Stewart; Sanjeeva Srivastava; Sudhir Srivastava; Fabio C. S. Nogueira; Gilberto B. Domont; Yves Vandenbrouck; Maggie P. Y. Lam; Sara Wennersten; Juan Antonio Vizcaino; Marc Wilkins; Jochen M. Schwenk; Emma Lundberg; Nuno Bandeira; Gyorgy Marko-Varga; Susan T. Weintraub; Charles Pineau; Ulrike Kusebauch; Robert L. Moritz; Seong Beom Ahn; Magnus Palmblad; Michael P. Snyder; Ruedi Aebersold; Mark S. Baker

doi:10.1038/s41467-020-19045-9

A high-stringency blueprint of the human proteome

Subash Adhikari, Edouard C. Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young-Ki Paik, Christopher M. Overall, Fernando J. Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlen, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua L. Justice, Joshua LaBaer, Henry Rodriguez, Fuchu HeMarkus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C. S. Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P. Y. Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M. Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T. Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P. Snyder, Ruedi Aebersold, Mark S. Baker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

183 Citations (Scopus)

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Abstract

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Original language	English
Article number	5301
Pages (from-to)	1-16
Number of pages	16
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19045-9
Publication status	Published - 16 Oct 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Access to Document

10.1038/s41467-020-19045-9Licence: CC BY

Publisher version (open access)Final published version, 1.62 MBLicence: CC BY

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Adhikari, S., Nice, E. C., Deutsch, E. W., Lane, L., Omenn, G. S., Pennington, S. R., Paik, Y.-K., Overall, C. M., Corrales, F. J., Cristea, I. M., Van Eyk, J. E., Uhlen, M., Lindskog, C., Chan, D. W., Bairoch, A., Waddington, J. C., Justice, J. L., LaBaer, J., Rodriguez, H., ... Baker, M. S. (2020). A high-stringency blueprint of the human proteome. Nature Communications, 11(1), 1-16. Article 5301. https://doi.org/10.1038/s41467-020-19045-9

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title = "A high-stringency blueprint of the human proteome",

abstract = "The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4\% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.",

author = "Subash Adhikari and Nice, \{Edouard C.\} and Deutsch, \{Eric W.\} and Lydie Lane and Omenn, \{Gilbert S.\} and Pennington, \{Stephen R.\} and Young-Ki Paik and Overall, \{Christopher M.\} and Corrales, \{Fernando J.\} and Cristea, \{Ileana M.\} and \{Van Eyk\}, \{Jennifer E.\} and Mathias Uhlen and Cecilia Lindskog and Chan, \{Daniel W.\} and Amos Bairoch and Waddington, \{James C.\} and Justice, \{Joshua L.\} and Joshua LaBaer and Henry Rodriguez and Fuchu He and Markus Kostrzewa and Peipei Ping and Gundry, \{Rebekah L.\} and Peter Stewart and Sanjeeva Srivastava and Sudhir Srivastava and Nogueira, \{Fabio C. S.\} and Domont, \{Gilberto B.\} and Yves Vandenbrouck and Lam, \{Maggie P. Y.\} and Sara Wennersten and Vizcaino, \{Juan Antonio\} and Marc Wilkins and Schwenk, \{Jochen M.\} and Emma Lundberg and Nuno Bandeira and Gyorgy Marko-Varga and Weintraub, \{Susan T.\} and Charles Pineau and Ulrike Kusebauch and Moritz, \{Robert L.\} and Ahn, \{Seong Beom\} and Magnus Palmblad and Snyder, \{Michael P.\} and Ruedi Aebersold and Baker, \{Mark S.\}",

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Adhikari, S, Nice, EC, Deutsch, EW, Lane, L, Omenn, GS, Pennington, SR, Paik, Y-K, Overall, CM, Corrales, FJ, Cristea, IM, Van Eyk, JE, Uhlen, M, Lindskog, C, Chan, DW, Bairoch, A, Waddington, JC, Justice, JL, LaBaer, J, Rodriguez, H, He, F, Kostrzewa, M, Ping, P, Gundry, RL, Stewart, P, Srivastava, S, Srivastava, S, Nogueira, FCS, Domont, GB, Vandenbrouck, Y, Lam, MPY, Wennersten, S, Vizcaino, JA, Wilkins, M, Schwenk, JM, Lundberg, E, Bandeira, N, Marko-Varga, G, Weintraub, ST, Pineau, C, Kusebauch, U, Moritz, RL, Ahn, SB, Palmblad, M, Snyder, MP, Aebersold, R & Baker, MS 2020, 'A high-stringency blueprint of the human proteome', Nature Communications, vol. 11, no. 1, 5301, pp. 1-16. https://doi.org/10.1038/s41467-020-19045-9

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AU - Adhikari, Subash

AU - Nice, Edouard C.

AU - Deutsch, Eric W.

AU - Lane, Lydie

AU - Omenn, Gilbert S.

AU - Pennington, Stephen R.

AU - Paik, Young-Ki

AU - Overall, Christopher M.

AU - Corrales, Fernando J.

AU - Cristea, Ileana M.

AU - Van Eyk, Jennifer E.

AU - Uhlen, Mathias

AU - Lindskog, Cecilia

AU - Chan, Daniel W.

AU - Bairoch, Amos

AU - Waddington, James C.

AU - Justice, Joshua L.

AU - LaBaer, Joshua

AU - Rodriguez, Henry

AU - He, Fuchu

AU - Kostrzewa, Markus

AU - Ping, Peipei

AU - Gundry, Rebekah L.

AU - Stewart, Peter

AU - Srivastava, Sanjeeva

AU - Srivastava, Sudhir

AU - Nogueira, Fabio C. S.

AU - Domont, Gilberto B.

AU - Vandenbrouck, Yves

AU - Lam, Maggie P. Y.

AU - Wennersten, Sara

AU - Vizcaino, Juan Antonio

AU - Wilkins, Marc

AU - Schwenk, Jochen M.

AU - Lundberg, Emma

AU - Bandeira, Nuno

AU - Marko-Varga, Gyorgy

AU - Weintraub, Susan T.

AU - Pineau, Charles

AU - Kusebauch, Ulrike

AU - Moritz, Robert L.

AU - Ahn, Seong Beom

AU - Palmblad, Magnus

AU - Snyder, Michael P.

AU - Aebersold, Ruedi

AU - Baker, Mark S.

N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/10/16

Y1 - 2020/10/16

N2 - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

AB - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

UR - http://purl.org/au-research/grants/nhmrc/1010303

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EP - 16

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JF - Nature Communications

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ER -

A high-stringency blueprint of the human proteome

Abstract

Bibliographical note

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Colorectal Cancer Membrane Protein Interactomics (A Major Discriminator of Clinical Outcome)

Deciphering the kidney matrisome: identification and quantification of renal extracellular matrix proteins in healthy mice

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A high-stringency blueprint of the human proteome

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Projects

Colorectal Cancer Membrane Protein Interactomics (A Major Discriminator of Clinical Outcome)

Research output

Deciphering the kidney matrisome: identification and quantification of renal extracellular matrix proteins in healthy mice

Cite this