A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR)

Maija R. J. Kohonen-Corish*, Yao Wang, William F. Doe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.

Original languageEnglish
Pages (from-to)124-125
Number of pages2
JournalHuman Genetics
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1996
Externally publishedYes

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