A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR)

Maija R. J. Kohonen-Corish; Yao Wang; William F. Doe

doi:10.1007/BF00218847

A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR)

Maija R. J. Kohonen-Corish^*, Yao Wang, William F. Doe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.

Original language	English
Pages (from-to)	124-125
Number of pages	2
Journal	Human Genetics
Volume	97
Issue number	1
DOIs	https://doi.org/10.1007/BF00218847
Publication status	Published - Jan 1996
Externally published	Yes

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abstract = "We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.",

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AB - We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.

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A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR)

Abstract

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