A low body temperature on arrival at hospital following out-of-hospital-cardiac-arrest is associated with increased mortality in the TTM-study

Jan Hovdenes*, Kjetil Røysland, Niklas Nielsen, Jesper Kjaergaard, Michael Wanscher, Christian Hassager, Jørn Wetterslev, Tobias Cronberg, David Erlinge, Hans Friberg, Yvan Gasche, Janneke Horn, Michael Kuiper, Tommaso Pellis, Pascal Stammet, Matthew P. Wise, Anders Åneman, Jan Frederik Bugge

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Aim: To investigate the association of temperature on arrival to hospital after out-of-hospital-cardiac arrest (OHCA) with the primary outcome of mortality, in the targeted temperature management (TTM) trial.

Methods: The TTM trial randomized 939 patients to TTM at 33 or 36 °C for 24 h. Patients were categorized according to their recorded body temperature on arrival and also categorized to groups of patients being actively cooled or passively rewarmed.

Results: OHCA patients having a temperature ≤34.0 °C on arrival at hospital had a significantly higher mortality compared to the OHCA patients with a higher temperature on arrival. A low body temperature on arrival was associated with a longer time to return of spontaneous circulation (ROSC) and duration of transport time to hospital. Patients who were actively cooled or passively rewarmed during the first 4 h had similar mortality.

In a multivariate logistic regression model mortality was significantly related to time from OHCA to ROSC, time from OHCA to advanced life support (ALS), age, sex and first registered rhythm. None of the temperature related variables (included the TTM-groups) were significantly related to mortality.

Conclusion: OHCA patients with a temperature ≤34.0 °C on arrival have a higher mortality than patients with a temperature ≥34.1 °C on arrival. A low temperature on arrival is associated with a long time to ROSC. Temperature changes and TTM-groups were not associated with mortality in a regression model.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalResuscitation
Volume107
DOIs
Publication statusPublished - 1 Oct 2016
Externally publishedYes

Keywords

  • Body temperature on arrival at hospital
  • Cardiac arrest
  • Temperature management

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