A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

Research output: Contribution to journalArticle

Abstract

Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.

Original languageEnglish
Pages (from-to)3800-3803
Number of pages4
JournalBiomaterials Science
Volume8
Issue number14
Early online date15 Jun 2020
DOIs
Publication statusPublished - 21 Jul 2020

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