A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

Kalpeshkumar Giri; Michael Lau; Inga Kuschnerus; Irene Moroni; Alfonso E. Garcia-Bennett

doi:10.1039/d0bm00445f

A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

Kalpeshkumar Giri, Michael Lau, Inga Kuschnerus, Irene Moroni, Alfonso E. Garcia-Bennett

ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.

Original language	English
Pages (from-to)	3800-3803
Number of pages	4
Journal	Biomaterials Science
Volume	8
Issue number	14
Early online date	15 Jun 2020
DOIs	https://doi.org/10.1039/d0bm00445f
Publication status	Published - 21 Jul 2020

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abstract = "Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.",

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AU - Giri, Kalpeshkumar

AU - Lau, Michael

AU - Kuschnerus, Inga

AU - Moroni, Irene

AU - Garcia-Bennett, Alfonso E.

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A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

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