A Metal–polymer hybrid biomimetic system for use in the chemodynamic-enhanced photothermal therapy of cancers

Lingdan Kong, Feng Yuan, Pingping Huang, Lu Yan, Zhenzhai Cai, Tom Lawson, Wencan Wu*, Shulei Chou, Yong Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This article reports the fabrication of a smart biomimetic enzyme system, which incorporates a pH-responsive chemodynamic therapy (CDT) combined with a photothermal (PTT) therapy approach in resolving the high recurrence rate of deadly cancers. The resulting enzyme system comprises copper sulfide (CuS) nanoparticle (NP) cores as Fenton-like catalysts, and a photothermal-active generation 5 poly(amidoamine) (G5) dendrimer as a template for the entrapment of Cu NPs and the compression of glucose oxidase (GOD). GOD is introduced to produce H2O2 necessary in the sequential Fenton-like reaction, and this generates hydroxyl radicals that kill the cancerous cells. Polyethylene glycol is added to the system to improve biocompatibility. Mechanism study suggests that the constructed CuS/G5-GOD-based system has a better Fenton-like catalytic activity than a Fe3O4-GOD-based system. This allows the further inhibition on the residual tumors from recurrence and metastasis through CDT after being treated by PTT. The developed smart nanoscale biomimetic system shows high efficiency for breast cancer suppression from recurrence and metastasis by combining PTT with a pH-responsive CDT. It has the potential to resolve the essential issue of cancer recurrence after its initial clinic treatment.

Original languageEnglish
Article number2004161
Pages (from-to)1-10
Number of pages10
JournalSmall
Volume16
Issue number43
DOIs
Publication statusPublished - 27 Oct 2020

Keywords

  • cancer metastasis
  • cancer recurrence
  • chemodynamic therapy
  • nanobiomimetic enzymes
  • photothermal therapy

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