A microfluidic needle for sampling and delivery of chemical signals by segmented flows

Shilun Feng, Guozhen Liu, Lianmei Jiang, Yonggang Zhu, Ewa M. Goldys, David W. Inglis*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference abstract

Abstract

This novel microfluidic needle-like device consist of parallel hydrophobic channels and seven 2 µm hydrophilic capillaries at the tip. The Laplace pressure in these capillaries creates a 19 kPa barrier pressure that prevents oil from exiting the hydrophobic channels. We demonstrated the delivery and sampling of aqueous droplets through these capillaries. There is a linear relationship between the recorded fluorescence intensity of samples and the external sampled dye concentration (10 to 40 µg/mL). We measured a response time of approximately 5 s. It will be a useful tool for in vivo on-line detection of chemical signals that change at sub 10s time scales.

Original languageEnglish
Title of host publicationThe 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages346-347
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2017
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (21st : 2017) - Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21st

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (21st : 2017)
Abbreviated titleMicroTAS 2017
CountryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • needle
  • segmented flow
  • delivery
  • sampling

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    Feng, S., Liu, G., Jiang, L., Zhu, Y., Goldys, E. M., & Inglis, D. W. (2017). A microfluidic needle for sampling and delivery of chemical signals by segmented flows. In The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 346-347). Chemical and Biological Microsystems Society.