A model of the pathophysiology of cerebral arteriovenous malformations by a carotid-jugular fistula in the rat

Michael K. Morgan*, Robert E. Anderson, Thoralf M. Sundt

*Corresponding author for this work

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A model of a carotid-jugular fistula in the rat was created such that the arterial feeding vessel is derived from the intracranial arterial circulation and the venous drainage communicates with a major intracranial venous drainage system. The fistula was created in 28 rats on the right side with an additional 11 rats designed as controls with a right carotid ligation and 6 rats without previous surgery. After 12 weeks convalescence, 6 rats with a carotid-jugular fistula and 6 rats without previous surgery underwent cerebral angiography. All fistulae were patent and the model was verified. All of the 33 remaining rats underwent regional cerebral blood flow (rCBF) determination by [14C]iodoantipyrine autoradiography under barbiturate anesthesia. Of the rats with the fistula, 11 had this fistula obliterated 5 min prior to rCBF determination ('closed' grop) while 11 had rCBFs determined with the fistula ('open' group). The rCBF was measured from each hemisphere from 7 anatomical regions. The rCBF in the control animals ranged from a median of 82 to 112 ml/100 g/min, in the 'open fistula' group 46 to 68 ml/100 g/min, and in the 'closed' group 118 to 187 ml/100 g/min. This experimental model stimulates the pathophysiologic perturbations in the parenchyma induced by cerebral arteriovenous malformations. It supports the findings that non-infarctional hypoperfusion can result from arteriovenous malformations and that following extirpation of arteriovenous malformations hyperemia may cause.

Original languageEnglish
Pages (from-to)241-250
Number of pages10
JournalBrain Research
Volume496
Issue number1-2
DOIs
Publication statusPublished - 4 Sep 1989
Externally publishedYes

Keywords

  • Arteriovenous malformation
  • Autoradiography
  • Cerebral blood flow
  • Hyperemia
  • Rat

Fingerprint Dive into the research topics of 'A model of the pathophysiology of cerebral arteriovenous malformations by a carotid-jugular fistula in the rat'. Together they form a unique fingerprint.

  • Cite this