A Multi-component similarity measure for improved robustness of non-rigid registration of combined FDG PET-CT head and neck images

Y. Papastavrou*, D. Cash, D. Hawkes, B. Hutton

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

    1 Citation (Scopus)

    Abstract

    Our intention was to register combined FDG PET-CT head and neck images from multiple patients to a template image. We used a free-form deformation (FFD) nonrigid registration (NRR) algorithm. We aimed to overcome instances of mis-registration at the coarse scale that occur when using a similarity measure derived from the CT images alone. We proposed a multi-component (MC) similarity measure to improve the robustness of the registration by utilizing information from both the PET and the CT image. Information from all combinations of the dual modality dataset were incorporated into this measure. We defined the MC similarity measure to be a weighted sum of four components: the normalized sum of squared differences (SSD) for the CT-CT component and normalized mutual information (NMI) for the other components. This function was then used to register a group of combined PET-CT images demonstrating normal anatomy and FDG uptake to the template image. The performance of the registration was assessed by measuring the errors across three bony anatomical landmarks within the image. The results were compared to the registration using SSD of the CT images alone as a similarity measure. Registrations performed using this MC similarity measure demonstrated improved robustness compared to using the SSD of the CT images alone as a similarity measure.

    Original languageEnglish
    Title of host publication4th European Conference of the International Federation for Medical and Biological Engineering - ECIFMBE 2008
    EditorsJ. V. Sloten, P. Verdonck, M. Nyssen, J. Haueisen
    Pages433-435
    Number of pages3
    Volume22
    DOIs
    Publication statusPublished - 2008
    Event4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008 - Antwerp, Belgium
    Duration: 23 Nov 200827 Nov 2008

    Other

    Other4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008
    CountryBelgium
    CityAntwerp
    Period23/11/0827/11/08

    Keywords

    • FFD
    • Head
    • Neck
    • PET-CT
    • Registration

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