A multiple binary Markov Chain model for explaining the behaviour of diverse biological phenomena

D. K. Morris*, G. R. Wood, W. P. Baritompa, A. G. Keen

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    The behaviour of many biological systems can be attributed to that of a large number of units, with each unit swinging between two competing states. During the past few years efforts have been made (e.g., CHUNG and KENNEDY, 1996) to describe such discrete systems using a multiple binary Markov chain model. Here we explore the gamut of these models and classify their behaviour into five qualitatively distinct types, corresponding to subregions of the parameter space. It is suggested that these model behaviours may correspond to behaviours observed in nature. A simple method for fitting the model to data is presented.

    Original languageEnglish
    Pages (from-to)601-614
    Number of pages14
    JournalBiometrical Journal
    Volume41
    Issue number5
    Publication statusPublished - 1999

    Keywords

    • Biological systems
    • Equilibrium
    • Excitation
    • Inhibition
    • Learning
    • Markov chain
    • Maximum likelihood
    • Synapse

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