A nano-sandwich device based graphene oxidese for monitoring cytokines

Guozhen Liu*, Meng Qi, Shilun Feng

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

Graphene oxide (GO), with its exceptional physical and chemical properties and biocompatibility, holds a tremendous potential for sensing applications. In this study, GO, acting both as the electron transfer bridge and the signal reporter, was attached on the interface to develop a label-free electrochemical nanosandwich device for detection of interleukin 6 (IL-6). The prepared nanosandwiches demonstrated high selectivity and stability for detection of IL-6 over the range of 1-300 pg mL−1 with the lowest detection limit of 1 pg mL−1. The device was successfully used for monitoring of IL-6 secretion in RAW cells and live mice.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Place of PublicationSan Diego, California
PublisherChemical and Biological Microsystems Society
Pages441-442
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2017
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • Aryldiazonium salt chemistry
  • Cytokines
  • Graphene oxides
  • In vivo detection
  • Nano-sandwich device

Fingerprint

Dive into the research topics of 'A nano-sandwich device based graphene oxidese for monitoring cytokines'. Together they form a unique fingerprint.

Cite this