TY - GEN
T1 - A nano-sandwich device based graphene oxidese for monitoring cytokines
AU - Liu, Guozhen
AU - Qi, Meng
AU - Feng, Shilun
PY - 2017
Y1 - 2017
N2 - Graphene oxide (GO), with its exceptional physical and chemical properties and biocompatibility, holds a tremendous potential for sensing applications. In this study, GO, acting both as the electron transfer bridge and the signal reporter, was attached on the interface to develop a label-free electrochemical nanosandwich device for detection of interleukin 6 (IL-6). The prepared nanosandwiches demonstrated high selectivity and stability for detection of IL-6 over the range of 1-300 pg mL−1 with the lowest detection limit of 1 pg mL−1. The device was successfully used for monitoring of IL-6 secretion in RAW cells and live mice.
AB - Graphene oxide (GO), with its exceptional physical and chemical properties and biocompatibility, holds a tremendous potential for sensing applications. In this study, GO, acting both as the electron transfer bridge and the signal reporter, was attached on the interface to develop a label-free electrochemical nanosandwich device for detection of interleukin 6 (IL-6). The prepared nanosandwiches demonstrated high selectivity and stability for detection of IL-6 over the range of 1-300 pg mL−1 with the lowest detection limit of 1 pg mL−1. The device was successfully used for monitoring of IL-6 secretion in RAW cells and live mice.
KW - Aryldiazonium salt chemistry
KW - Cytokines
KW - Graphene oxides
KW - In vivo detection
KW - Nano-sandwich device
UR - http://www.scopus.com/inward/record.url?scp=85079641673&partnerID=8YFLogxK
UR - https://cbmsociety.org/microtas/microtas_proceedings/
M3 - Conference proceeding contribution
AN - SCOPUS:85079641673
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 441
EP - 442
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
CY - San Diego, California
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -