A nanotube composite microelectrode for monitoring dopamine levels using cyclic voltammetry and differential pulse voltammetry

Y. H. Yun, M. J. Schulz*, A. Bange, W. R. Heineman, H. B. Halsall, V. N. Shanov, M. Behbehani, S. Pixley, A. Bhattacharya, Z. Dong, D. K Y Wong

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Needle-type nanotube composite microelectrodes were fabricated by injecting a carbon nanotube epoxy solution into pulled-glass tubes. Electrochemical impedance spectroscopy was used to study the complex impedance of the electrode and showed that the electron transfer resistance of the electrode decreases with an increase in the percentage of nanotubes in the epoxy. Cyclic voltammetry was performed under reducing conditions in 6.0mM K3Fe(CN)6 to examine the surface properties of the microelectrodes. The results showed a steady-state response up to 0.5 V/s attributable to radial diffusion with a high steady-state current density. Cyclic voltammetry and differential pulse voltammetry were then used to detect dopamine. The results showed a linear response with a sensitivity of 100nA/mM. Based on the cyclic voltammetry and differential pulse voltammetry results, needle-type nanotube composite microelectrodes are promising sensors for detecting neurotransmitters.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalProceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems
Volume220
Issue number2
DOIs
Publication statusPublished - 1 Jun 2006

Keywords

  • carbon nanotube
  • cyclic voltammetry
  • differential pulse voltammetry
  • dopamine
  • electrochemical impedance

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