A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100

Y. Parsons, R. M. Hall*, H. W. Stokes

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.

Original languageEnglish
Pages (from-to)2436-2439
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number11
Publication statusPublished - 1991

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