A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100

Y. Parsons; R. M. Hall; H. W. Stokes

A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100

Y. Parsons, R. M. Hall^*, H. W. Stokes

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.

Original language	English
Pages (from-to)	2436-2439
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	35
Issue number	11
Publication status	Published - 1991

Cite this

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title = "A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100",

abstract = "A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28\% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.",

author = "Y. Parsons and Hall, \{R. M.\} and Stokes, \{H. W.\}",

year = "1991",

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journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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T1 - A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100

AU - Parsons, Y.

AU - Hall, R. M.

AU - Stokes, H. W.

PY - 1991

Y1 - 1991

N2 - A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.

AB - A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.

UR - https://www.scopus.com/pages/publications/0026003203

M3 - Article

C2 - 1804022

AN - SCOPUS:0026003203

SN - 0066-4804

VL - 35

SP - 2436

EP - 2439

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100

Abstract

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