A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3-Independent Muscle Cell Death

Arkadiusz Orzechowski*, Michal Jank, Barbara Gajkowska, Tomasz Sadkowski, Michal Marek Godlewski

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-κB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume1010
DOIs
Publication statusPublished - 2003

Keywords

  • Caspase-3
  • Dexamethasone
  • Hydrogen peroxide
  • m-calpain
  • Muscle cell death

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