A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3-Independent Muscle Cell Death

Arkadiusz Orzechowski; Michal Jank; Barbara Gajkowska; Tomasz Sadkowski; Michal Marek Godlewski

doi:10.1196/annals.1299.035

A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3-Independent Muscle Cell Death

Arkadiusz Orzechowski^*, Michal Jank, Barbara Gajkowska, Tomasz Sadkowski, Michal Marek Godlewski

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-κB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	1010
DOIs	https://doi.org/10.1196/annals.1299.035
Publication status	Published - 2003

Keywords

Caspase-3
Dexamethasone
Hydrogen peroxide
m-calpain
Muscle cell death

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10.1196/annals.1299.035

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title = "A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3-Independent Muscle Cell Death",

abstract = "Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-κB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.",

keywords = "Caspase-3, Dexamethasone, Hydrogen peroxide, m-calpain, Muscle cell death",

author = "Arkadiusz Orzechowski and Michal Jank and Barbara Gajkowska and Tomasz Sadkowski and Godlewski, {Michal Marek}",

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T1 - A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3-Independent Muscle Cell Death

AU - Orzechowski, Arkadiusz

AU - Jank, Michal

AU - Gajkowska, Barbara

AU - Sadkowski, Tomasz

AU - Godlewski, Michal Marek

PY - 2003

Y1 - 2003

N2 - Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-κB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.

AB - Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-κB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.

KW - Caspase-3

KW - Dexamethasone

KW - Hydrogen peroxide

KW - m-calpain

KW - Muscle cell death

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U2 - 10.1196/annals.1299.035

DO - 10.1196/annals.1299.035

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SN - 0077-8923

VL - 1010

SP - 205

EP - 208

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

A Novel Antioxidant-Inhibited Dexamethasone-Mediated and Caspase-3-Independent Muscle Cell Death

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Keywords

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